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Electronic polymers in lipid membranes
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-8493-0114
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, no 11242Article in journal (Refereed) Published
Abstract [en]

Electrical interfaces between biological cells and man-made electrical devices exist in many forms, but it remains a challenge to bridge the different mechanical and chemical environments of electronic conductors (metals, semiconductors) and biosystems. Here we demonstrate soft electrical interfaces, by integrating the metallic polymer PEDOT-S into lipid membranes. By preparing complexes between alkyl-ammonium salts and PEDOT-S we were able to integrate PEDOT-S into both liposomes and in lipid bilayers on solid surfaces. This is a step towards efficient electronic conduction within lipid membranes. We also demonstrate that the PEDOT-S@alkyl-ammonium: lipid hybrid structures created in this work affect ion channels in the membrane of Xenopus oocytes, which shows the possibility to access and control cell membrane structures with conductive polyelectrolytes.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015. Vol. 5, no 11242
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-120045DOI: 10.1038/srep11242ISI: 000356090400002PubMedID: 26059023OAI: oai:DiVA.org:liu-120045DiVA: diva2:840009
Note

Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Research Council

Available from: 2015-07-06 Created: 2015-07-06 Last updated: 2017-12-04
In thesis
1. Self-doped Conjugated Polyelectrolytes for Bioelectronics Applications
Open this publication in new window or tab >>Self-doped Conjugated Polyelectrolytes for Bioelectronics Applications
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Self-doped conjugated polyelectrolytes (CPEs) are a class of conducting polymers constituted of a π-conjugated backbone and charged side groups. The ionic groups provide the counterions needed to balance the charged species formed in the CPEs backbones upon oxidation. As a result, addition of external counterions is not required, and the CPEs can be defined as selfdoped. The combination of their unique optical and electrical properties render them the perfect candidates for optoelectronic applications. Additionally, their “soft” nature provide for the mechanical compatibility necessary to interface with biological systems, rendering them promising materials for bioelectronics applications. CPEs solubility, aggregation state, and optoelectronic properties can be easily tuned by different means, such as blending or interaction with oppositely charged species (such as surfactants), in order to produce materials with the desired properties. In this thesis both the strategies have been explored to produce new functional materials that can be deposited to form a thin film and,  therefore, used as an active layer in organic electrochemical transistors (OECTs). Microstructure formation of the films as well as influence on devices operation and performance have been investigated. We also show that these methods can be exploited to produce materials whose uniquecombination of self-doping ability and hydrophobicity allows incorporation into the phospholipid double layer of biomembranes, while retaining their properties. As a result, self-doped CPEs can be used both as sensing elements to probe the physical state of biomembranes, and as functional ones providing them with new functionalities, such as electrical conductivity. Integration of conductive electronic biomembranes into OECTs devices has brought us one step forward on the interface of manmade technologies with biological systems.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2016. 68 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1802
National Category
Materials Chemistry Textile, Rubber and Polymeric Materials Inorganic Chemistry Other Materials Engineering Polymer Chemistry
Identifiers
urn:nbn:se:liu:diva-132731 (URN)10.3384/diss.diva-132731 (DOI)9789176856451 (ISBN)
Public defence
2016-12-15, Plank, Fysikhuset, Campus Valla, Linköping, 10:15 (English)
Opponent
Supervisors
Available from: 2016-11-21 Created: 2016-11-21 Last updated: 2016-11-21Bibliographically approved
2. On decoration of biomolecular scaffolds with a conjugated polyelectrolyte
Open this publication in new window or tab >>On decoration of biomolecular scaffolds with a conjugated polyelectrolyte
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Biotemplating is the art of using a biological structure as a scaffold which is decorated with a functional material. In this fashion the structures will gain new functionalities and biotemplating offers a simple route of mass-producing mesoscopic material with new interesting properties. Biological structures are abundant and come in a great variety of elaborate and due to their natural origin they could be more suitable for interaction with biological systems than wholly synthetic materials. Conducting polymers are a novel class of material which was developed just 40 years ago and are well suited for interaction with biological material due to their organic composition. Furthermore the electronic properties of the conducting polymers can be tuned giving rise to dynamic control of the behavior of the material. Self-assembly processes are interesting since they do not require complicated or energy demanding processing conditions. This is particularly important as most biological materials are unstable at elevated temperatures or harsh environments. The main aim of this thesis is to show the possibility of using self-assembly to decorate a conducting polymer onto various biotemplates. Due to the intrinsic variety in charge, size and structure between the available natural scaffolds it is difficult, if not impossible, to find a universal method.

In this thesis we show how biotemplating can be used to create new hybrid materials by self-assembling a conducting polymer with biological structures based on DNA, protein, lipids and cellulose, and in this fashion create material with novel optical and electronic properties.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2017. 51 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1885
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:liu:diva-141675 (URN)10.3384/diss.diva-141675 (DOI)9789176854372 (ISBN)
Public defence
2017-10-19, Planck, Fysikhuset, Campus Valla, Linköping, 10:15 (English)
Opponent
Supervisors
Funder
Swedish Foundation for Strategic Research Knut and Alice Wallenberg Foundation
Available from: 2017-10-04 Created: 2017-10-04 Last updated: 2017-10-05Bibliographically approved

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Johansson, PatrikJullesson, DavidElfwing, AndersLiin, SaraMusumeci, ChiaraZeglio, EricaElinder, FredrikSolin, NiclasInganäs, Olle

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