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FamLinkX - implementation of a general model for likelihood computations for X-chromosomal marker data
Norwegian Institute Public Heatlh, Norway; Norwegian University of Life Science, Norway.
National Board Forens Med, Department Forens Genet and Forens Toxicol, SE-58758 Linkoping, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. National Board Forens Med, Department Forens Genet and Forens Toxicol, SE-58758 Linkoping, Sweden.
2015 (English)In: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 17Article in journal (Refereed) Published
Abstract [en]

The use of genetic markers located on the X chromosome has seen a significant increase in the last years and their utility has been well studied. This paper describes the software FamLinkX, freely available at http://www.famlink.se, implementing a new algorithm for likelihood computations accounting for linkage, linkage disequilibrium and mutations. It is obvious that such software is sought for among forensic users as more and more X-chromosomal markers become available. We provide some simulated examples demonstrating the utility of the implementation as well as its application in forensic casework. Though algebraic derivations are generally unfeasible, the paper outlines some theoretical considerations and provides a discussion on the validation of the software. The focus of this paper is to compare the software to existing methods in a forensic setting, perform a validation study as well as to provide an idea of the discriminatory power for X-chromosomal markers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 17
Keyword [en]
Linkage; X chromosome; FamLinkX; Linkage disequilibrium; Mutations
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120034DOI: 10.1016/j.fsigen.2015.02.007ISI: 000355918400001PubMedID: 25771099OAI: oai:DiVA.org:liu-120034DiVA: diva2:840027
Available from: 2015-07-06 Created: 2015-07-06 Last updated: 2015-07-06

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Tillmar, Andreas
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
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