liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
FamLinkX - implementation of a general model for likelihood computations for X-chromosomal marker data
Norwegian Institute Public Heatlh, Norway; Norwegian University of Life Science, Norway.
National Board Forens Med, Department Forens Genet and Forens Toxicol, SE-58758 Linkoping, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. National Board Forens Med, Department Forens Genet and Forens Toxicol, SE-58758 Linkoping, Sweden.
2015 (English)In: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 17Article in journal (Refereed) Published
Abstract [en]

The use of genetic markers located on the X chromosome has seen a significant increase in the last years and their utility has been well studied. This paper describes the software FamLinkX, freely available at, implementing a new algorithm for likelihood computations accounting for linkage, linkage disequilibrium and mutations. It is obvious that such software is sought for among forensic users as more and more X-chromosomal markers become available. We provide some simulated examples demonstrating the utility of the implementation as well as its application in forensic casework. Though algebraic derivations are generally unfeasible, the paper outlines some theoretical considerations and provides a discussion on the validation of the software. The focus of this paper is to compare the software to existing methods in a forensic setting, perform a validation study as well as to provide an idea of the discriminatory power for X-chromosomal markers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 17
Keyword [en]
Linkage; X chromosome; FamLinkX; Linkage disequilibrium; Mutations
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-120034DOI: 10.1016/j.fsigen.2015.02.007ISI: 000355918400001PubMedID: 25771099OAI: diva2:840027
Available from: 2015-07-06 Created: 2015-07-06 Last updated: 2015-07-06

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Tillmar, Andreas
By organisation
Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
In the same journal
Forensic Science International: Genetics
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 34 hits
ReferencesLink to record
Permanent link

Direct link