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Peripheral microvascular function is altered in young individuals at risk for hypertrophic cardiomyopathy and correlates with myocardial diastolic function
Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping. Lund University, Sweden.
Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
Lund University, Sweden.
Lund University, Sweden.
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2015 (English)In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 308, no 11, H1351-H1358 p.Article in journal (Refereed) Published
Abstract [en]

Hypertrophic cardiomyopathy (HCM) is a major cause of sudden cardiac death in the young. Based on previous reports of functional abnormalities in not only coronary but also peripheral vessels in adults with HCM, we aimed to assess both peripheral vascular and myocardial diastolic function in young individuals with an early stage of HCM and in individuals at risk for HCM. Children, adolescents, and young adults (mean age: 12 yr) with a family history of HCM who either had (HCM group; n = 36) or did not have (HCM-risk group; n = 30) echocardiography-documented left ventricular (LV) hypertrophy as well as healthy matched controls (n = 85) and healthy young athletes (n = 12) were included in the study. All underwent assessment with 12-lead electrocardiography, two-dimensional echocardiography, tissue Doppler imaging and laser Doppler with transdermal iontophoresis of ACh and sodium nitroprusside. LV thickness and mass were increased in HCM and athlete groups compared with control and HCM-risk groups. The mitral E-to-e ratio, measured via tissue Doppler, was increased in HCM (P less than 0.0001) and HCM-risk (P less than 0.01) groups compared with control and athlete groups, as were microvascular responses to ACh (HCM group: P less than 0.045 and HCM- risk group: P less than 0.02). Responses to ACh correlated with the E-to-e ratio (r = 0.5, P = 0.001). Microvascular responses to sodium nitroprusside were similar in all groups (P = 0.2). HCM-causing mutations or its familial history are associated with changes in cardiac diastolic function and peripheral microvascular function even before the onset of myocardial hypertrophy. Tissue Doppler can be used to differentiate HCM from physiological LV hypertrophy in young athletes.

Place, publisher, year, edition, pages
American Physiological Society , 2015. Vol. 308, no 11, H1351-H1358 p.
Keyword [en]
early diagnosis; myocardial hypertrophy; diastology; endothelium; athletes heart
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:liu:diva-120168DOI: 10.1152/ajpheart.00714.2014ISI: 000356269600006PubMedID: 25795712OAI: diva2:841460

Funding Agencies|Samariten Fundation; Anna-Lisa and Sven-Erik Lundgren Foundation; Skane University Hospital Lund; University Hospital Linkoping

Available from: 2015-07-13 Created: 2015-07-13 Last updated: 2015-08-20

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Department of Paediatrics in Linköping
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American Journal of Physiology. Heart and Circulatory Physiology
Cardiac and Cardiovascular Systems

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