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Helicobacter pylori vesicles carrying CagA localize in the vicinity of cell-cell contacts and induce histone H1 binding to ATP in epithelial cells
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Umeå University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Umeå University, Sweden.
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2015 (English)In: FEMS Microbiology Letters, ISSN 0378-1097, E-ISSN 1574-6968, Vol. 362, no 11, fnv076- p.Article in journal (Refereed) Published
Abstract [en]

Helicobacter pylori produces outer membrane vesicles (OMV), delivering bacterial substances including the oncogenic cytotoxin-associated CagA protein to their surroundings. We investigated the effects of H. pylori OMV carrying CagA (OMV-CagA) on cell junctions and ATP-binding proteome of epithelial monolayers, using proteomics, mass spectrometry and imaging. OMV-CagA localized in close vicinity of ZO-1 tight junction protein and induced histone H1 binding to ATP. We suggest the expression of novel events in the interactions between H. pylori OMV and epithelia, which may have an influence on host gene transcription and lead to different outcomes of an infection and development of cancer.

Place, publisher, year, edition, pages
Oxford University Press (OUP): Policy B - Oxford Open Option D , 2015. Vol. 362, no 11, fnv076- p.
Keyword [en]
Helicobacter pylori; outer membrane vesicles; CagA; ATP-proteome; histone H1; epithelial cell-cell junctions
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120236DOI: 10.1093/femsle/fnv076ISI: 000356890900007PubMedID: 25956174OAI: oai:DiVA.org:liu-120236DiVA: diva2:842627
Note

Funding Agencies|Swedish Research Council [2005-4636, 2008-3000, 2014-4361, 2007-3483, 2010-3045]; Euro-BioImaging; Magnus Bergvalls Foundation; Faculty of Health Sciences, Linkoping University; Kempe Memorial Foundation; Cancerfonden [CAN 2012/759]; Cancerforskningsfonden i Norrland; Insamlingstiftelsen for medicinsk forskning vid Umea universitet

Available from: 2015-07-21 Created: 2015-07-20 Last updated: 2015-07-21

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Turkina, MariaMagnusson, Karl-EricVikström, Elena
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