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N-terminal pro-C-type natriuretic peptide in serum associated with bone destruction in patients with multiple myeloma
University of Copenhagen, Denmark.
University of Copenhagen, Denmark.
Aarhus University Hospital, Denmark.
Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology. Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
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2015 (English)In: Biomarkers in Medicine, ISSN 1752-0363, E-ISSN 1752-0371, Vol. 9, no 7, 679-689 p.Article in journal (Refereed) Published
Abstract [en]

Aim: To examine whether N-terminal proCNP concentrations in serum is associated with bone destruction in patients with multiple myeloma. Materials and methods: N-terminal proCNP and biochemical bone markers were measured in 153 patients. Radiographic bone disease and skeletal-related events were evaluated at specific time-points. Results: N-terminal proCNP concentrations increased with age. High N-terminal proCNP concentrations were associated with high-risk disease and renal impairment. Renal function explained 22% of the variation. N-terminal proCNP concentrations correlated with serum bone ALP and serum PINP, but lacked association with bone resorption markers, radiographic bone disease and skeletal-related events. Conclusion: Serum N-terminal proCNP are associated with bone formation activity in patients with multiple myeloma, but should be interpreted with caution in patients with renal impairment.

Place, publisher, year, edition, pages
Future Medicine , 2015. Vol. 9, no 7, 679-689 p.
Keyword [en]
CNP; bone disease; multiple myeloma; natriuretic peptides; renal impairment
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120479DOI: 10.2217/BMM.15.35ISI: 000357950100008PubMedID: 26174842OAI: oai:DiVA.org:liu-120479DiVA: diva2:845520
Available from: 2015-08-12 Created: 2015-08-11 Last updated: 2016-03-24

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Ahlberg, Lucia
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Department of HaematologyDivision of Clinical SciencesFaculty of Medicine and Health Sciences
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