Energy Barrier Reduction for the Double Proton-Transfer Reaction in Guanine-Cytosine DNA Base Pair on a Gold Surface
2015 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 119, no 27, 15735-15741 p.Article in journal (Refereed) Published
We investigate, by means of first-principles calculations, the impact of a gold surface on the proton-transfer of the guanine-cytosine (GC) DNA base pair. Our calculations employ density functional improvements to correct van der Waals interactions and properly treat a weakly bound GC pair at an Au(111) surface. We adopted the simultaneous double proton-transfer (SDPT) mechanism proposed by Lowdin, which may lead to a spontaneous mutation in the structure of DNA from specific tautomerization involving the base pairs. Our calculated differences in the energetics and kinetics of the SDPT in the GC pair, when in contact with an inert gold surface, indicate a reduction of about 31% in the activation energy barrier of the GC/Au(111) tautomeric equilibrium. This finding gives strong evidence that tautomerism of DNA base pairs, binding to a noble surface, may be indeed relevant for the assessment of a possible point mutation, which could be induced by the presence of gold nanoparticles during DNA replication.
Place, publisher, year, edition, pages
American Chemical Society , 2015. Vol. 119, no 27, 15735-15741 p.
nucleobase tautomerization; nanotoxicology; van der Waals interactions; density functional theory; double proton-transfer; gold surface; mutation
IdentifiersURN: urn:nbn:se:liu:diva-120452DOI: 10.1021/acs.jpcc.5b04149ISI: 000357964900104OAI: oai:DiVA.org:liu-120452DiVA: diva2:845594
Funding Agencies|Swedish Research Council (VR) [348-2014-4249]; Linkoping Linnaeus Initiative for Novel Functionalized Materials (LiLi-NFM, VR); Swedish Foundation for Strategic Research (SSF) [RMA11-0029]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)2015-08-122015-08-112015-09-01