liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Olfactory Discrimination Learning in an Outbred and an Inbred Strain of Mice.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-5583-2697
2015 (English)In: Chemical Senses, ISSN 0379-864X, E-ISSN 1464-3553, Vol. 40, no 7, 489-496 p.Article in journal (Refereed) Published
Abstract [en]

The present study compared olfactory discrimination learning in CD-1 mice, a widely used outbred strain of mice with that of C57BL/6J mice, one of the most widely used inbred mouse strains. Using an automated olfactometer and a standard operant conditioning procedure, I found that CD-1 mice needed 60 trials to reach learning criterion in an initial 2-odor discrimination task. They improved in learning speed in subsequent discrimination tasks in which either the rewarded or the unrewarded stimulus was replaced for a new stimulus. C57BL/6J mice, in contrast, needed 120 trials to reach learning criterion in an initial 2-odor discrimination task and also needed significantly more trials than the CD-1 mice in 3 of the 4 subsequent discrimination tasks. Further, the results showed that discrimination learning performance of both mouse strains was largely unaffected by the odor stimuli used. The results of the present study demonstrate differences between an outbred and an inbred strain of mice with regard to odor discrimination learning, a classical measure of cognitive performance in comparative psychology. Thus, they emphasize the need to be careful with generalizing statements as to cognitive or sensory abilities of Mus musculus when inbred strains of mice are used.

Place, publisher, year, edition, pages
Oxford University Press, 2015. Vol. 40, no 7, 489-496 p.
Keyword [en]
C57BL/6J mice, CD-1 mice, intramodal transfer tasks, olfactory discrimination learning
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-120596DOI: 10.1093/chemse/bjv032ISI: 000361528400006PubMedID: 26123553OAI: oai:DiVA.org:liu-120596DiVA: diva2:846739
Available from: 2015-08-18 Created: 2015-08-18 Last updated: 2015-10-19

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Laska, Matthias
By organisation
BiologyFaculty of Science & Engineering
In the same journal
Chemical Senses
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 69 hits
ReferencesLink to record
Permanent link

Direct link