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Effects of Experimental Tooth Clenching on Pain and Intramuscular Release of 5-HT and Glutamate in Patients With Myofascial TMD
Malmö University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Region Östergötland, Heart and Medicine Center, Occupational and Environmental Medicine Center.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Malmö University, Sweden; Skåne University Hospital, Sweden.
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2015 (English)In: The Clinical Journal of Pain, ISSN 0749-8047, E-ISSN 1536-5409, Vol. 31, no 8, 740-749 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: It has been suggested that tooth clenching may be associated with local metabolic changes, and is a risk factor for myofascial temporomandibular disorders (M-TMD). This study investigated the effects of experimental tooth clenching on the levels of 5-HT, glutamate, pyruvate, and lactate, as well as on blood flow and pain intensity, in the masseter muscles of M-TMD patients. Methods: Fifteen patients with M-TMD and 15 pain-free controls participated. Intramuscular microdialysis was performed to collect 5-HT, glutamate, pyruvate, and lactate and to assess blood flow. Two hours after the insertion of a microdialysis catheter, participants performed a 20-minute repetitive tooth clenching task (50% of maximal voluntary contraction). Pain intensity was measured throughout. Results: A significant effect of group (P less than 0.01), but not of time, was observed on 5-HT levels and blood flow. No significant effects of time or group occurred on glutamate, pyruvate, or lactate levels. Time and group had significant main effects on pain intensity (P less than 0.05 and less than 0.001). No significant correlations were identified between: (1) 5-HT, glutamate, and pain intensity; or between (2) pyruvate, lactate, and blood flow. Discussion: This experimental tooth clenching model increased jaw muscle pain levels in M-TMD patients and evoked low levels of jaw muscle pain in controls. M-TMD patients had significantly higher levels of 5-HT than controls and significantly lower blood flow. These 2 factors may facilitate the release of other algesic substances that may cause pain.

Place, publisher, year, edition, pages
Lippincott, Williams andamp; Wilkins , 2015. Vol. 31, no 8, 740-749 p.
Keyword [en]
temporomandibular disorders; serotonin; glutamate; masseter muscle; bruxism; microdialysis
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120641DOI: 10.1097/AJP.0000000000000154ISI: 000358207900009PubMedID: 25232860OAI: oai:DiVA.org:liu-120641DiVA: diva2:847596
Note

Funding Agencies|Faculty of Odontology at Malmo "University, Malmo", Sweden; Swedish Dental Society; Swedish Rheumatism Association; Karolinska Institutet, Huddinge, Sweden; Swedish Research Counsil

Available from: 2015-08-20 Created: 2015-08-20 Last updated: 2016-04-25

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Ghafouri, BijarGerdle, Björn
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Division of Community MedicineDivision of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesPain and Rehabilitation CenterOccupational and Environmental Medicine Center
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