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Platelets, gender and acute cerebral infarction
Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Region Östergötland, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Medicine and Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
2015 (English)In: Journal of Translational Medicine, ISSN 1479-5876, E-ISSN 1479-5876, ISSN ISSN 1479-5876, Vol. 13, no 267Article in journal (Refereed) Published
Abstract [en]

Objective

Platelets may well be significant in the pathogenesis of cerebral infarction. Platelets vary substantially according to gender. The scope of our current work is to establish if female and male stroke sufferers differ regarding platelet reactivity.

Patients and methods

73 Consecutive individuals stricken by acute ischemic cerebral infarction (31 females, 42 males) participated. All stroke subtypes were included. Platelet counts was determined electronically. Platelet reactivity i.e. the presence of surface-bound fibrinogen following provocation was analyzed with a flow cytometer. ADP (1.7 μmol/L) and a thrombin receptor agonist (TRAP-6) (57 μmol/L) were the agonists used.

Results

Female stroke sufferers had higher platelet counts (p = 0.013) but their platelets were less reactive. The p values were (p = 0.038) and (p = 0.016) for ADP and TRAP-6, respectively.

Conclusion

The current study demonstrates that women suffering acute cerebral infarction have less reactive platelets. It is concluded that gender affects platelets. Our study indicates that it may be beneficial to individualize platelet inhibition of stroke sufferers according to gender.

Place, publisher, year, edition, pages
BioMed Central, 2015. Vol. 13, no 267
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120697DOI: 10.1186/s12967-015-0630-xOAI: oai:DiVA.org:liu-120697DiVA: diva2:847946
Available from: 2015-08-21 Created: 2015-08-21 Last updated: 2017-12-04Bibliographically approved

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Järemo, PetterMilovanovic, Micha

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Department of Internal Medicine in NorrköpingDivision of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Internal Medicine in NorrköpingDivision of Health, Activity and Care
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