liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Polymorphisms in the ABCB1 gene and effect on outcome and toxicity in childhood acute lymphoblastic leukemia
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. University of Copenhagen Hospital, Denmark.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. KTH Royal Institute Technology, Sweden; National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
Rigshosp, Denmark.
Bispebjerg Hospital, Denmark.
Show others and affiliations
2015 (English)In: The Pharmacogenomics Journal, ISSN 1470-269X, E-ISSN 1473-1150, Vol. 15, no 4, 372-379 p.Article in journal (Refereed) Published
Abstract [en]

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect outcome and toxicity in childhood acute lymphoblastic leukemia (ALL). We studied 522 Danish children with ALL, 93% of all those eligible. Risk of relapse was increased 2.9-fold for patients with the 1199GA variant versus 1199GG (P = 0.001), and reduced 61% and 40%, respectively, for patients with the 3435CT or 3435TT variants versus 3435CC (overall P = 0.02). The degree of bone marrow toxicity during doxorubicin, vincristine and prednisolone induction therapy was more prominent in patients with 3435TT variant versus 3435CT/3435CC (P = 0.01/P less than 0.0001). We observed more liver toxicity after high-dose methotrexate in patients with 3435CC variant versus 3435CT/TT ( P = 0.03). In conclusion, there is a statistically significant association between ABCB1 polymorphisms, efficacy and toxicity in the treatment of ALL, and ABCB1 1199G greater than A may be a new possible predictive marker for outcome in childhood ALL.

Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Hybrid Model Option B , 2015. Vol. 15, no 4, 372-379 p.
National Category
Clinical Medicine Hematology
Identifiers
URN: urn:nbn:se:liu:diva-120735DOI: 10.1038/tpj.2014.81ISI: 000358448500012PubMedID: 25582575OAI: oai:DiVA.org:liu-120735DiVA: diva2:848221
Note

Funding Agencies|Swedish Cancer Society; Swedish Research Council; County Concil in Ostergotland; Danish Childhood Cancer Foundation; University Hospital Rigshospitalet, Denmark

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2017-12-04

Open Access in DiVA

fulltext(487 kB)133 downloads
File information
File name FULLTEXT01.pdfFile size 487 kBChecksum SHA-512
26574755126676ac405f8951f37c6e99f5e143116facf6ece3f78462dccaa3007157f7fd4fec8701c473bd58d179a1612ef8e444e0ace0f1882aa512b108b228
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Gregers, JannieGreen, HenrikPeterson, Curt

Search in DiVA

By author/editor
Gregers, JannieGreen, HenrikPeterson, Curt
By organisation
Division of Drug ResearchFaculty of Medicine and Health SciencesDepartment of Oncology
In the same journal
The Pharmacogenomics Journal
Clinical MedicineHematology

Search outside of DiVA

GoogleGoogle Scholar
Total: 133 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 197 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf