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Does allergy begin in utero?
University of Southampton, England.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
University of Southampton, England; University of Southampton, England.
2015 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 26, no 5, 394-402 p.Article, review/survey (Refereed) Published
Abstract [en]

It has been recognized for centuries that allergic disease runs in families, implying a role for genetic factors in determining individual susceptibility. More recently, a range of evidence shows that many of these genetic factors, together with in utero environmental exposures, lead to the development of allergic disease through altered immune and organ development. Environmental exposures during pregnancy including diet, nutrient intake and toxin exposures can alter the epigenome and interact with inherited genetic and epigenetic risk factors to directly and indirectly influence organ development and immune programming. Understanding of these factors will be essential in identifying at-risk individuals and possible development of therapeutic interventions for the primary prevention of allergic disease. In this review, we summarize the evidence that suggests allergic disease begins in utero, together with possible mechanisms for the effect of environmental exposures during pregnancy on allergic disease risk, including epigenetics.

Place, publisher, year, edition, pages
Wiley: 12 months , 2015. Vol. 26, no 5, 394-402 p.
Keyword [en]
allergy; early origin; environment; epigenetics; in utero effects
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120734DOI: 10.1111/pai.12408ISI: 000358698100001PubMedID: 26011578OAI: oai:DiVA.org:liu-120734DiVA: diva2:848225
Note

Funding Agencies|National Institutes of Health, USA [R01-AI091905]; COST action [BM1201]

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2015-08-24

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Huoman, Johanna
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
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