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Elevated body swing test after focal cerebral ischemia in rodents: methodological considerations
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics.ORCID iD: 0000-0001-8813-0384
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.
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2015 (English)In: BMC neuroscience (Online), ISSN 1471-2202, E-ISSN 1471-2202, Vol. 16, no 50Article in journal (Refereed) Published
Abstract [en]

Background: The elevated body swing test (EBST) is a behavioral test used to evaluate experimental stroke in rodents. The basic idea is that when the animal is suspended vertically by the tail, it will swing its head laterally to the left or right depending on lesion side. In a previous study from our lab using the EBST after middle cerebral artery occlusion (MCAo), rats swung contralateral to the infarct day 1 post-MCAo, but ipsilateral day 3 post-MCAo. This shift was unexpected and prompted us to perform the present study. First, the literature was systematically reviewed to elucidate whether a similar shift had been noticed before, and if consensus existed regarding swing direction. Secondly, an experiment was conducted to systematically investigate the suggested behavior. Eighty-three adult male and female Sprague-Dawley rats were subjected to MCAo or sham surgery and the EBST was performed up to 7 days after the lesion. Results: Both experimentally and through systematic literature review, the present study shows that the direction of biased swing activity in the EBST for rodents after cerebral ischemia can differ and even shift over time in some situations. The EBST curve for females was significantly different from that of males after the same occlusion time (p = 0.023). Conclusions: This study highlights the importance of adequate reporting of behavioral tests for lateralization and it is concluded that the EBST cannot be recommended as a test for motor asymmetry after MCAo in rats.

Place, publisher, year, edition, pages
BioMed Central / Springer Verlag (Germany) , 2015. Vol. 16, no 50
Keyword [en]
Brain infarction; Focal cerebral ischemia; Middle cerebral artery occlusion; Elevated body swing test; Rodents; Rats; Lateralization
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-120862DOI: 10.1186/s12868-015-0189-8ISI: 000358984700001PubMedID: 26242584OAI: oai:DiVA.org:liu-120862DiVA: diva2:849446
Note

Funding Agencies|Region Ostergotland/Linkoping University, Sweden

Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2017-12-04

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Ingberg, EdvinTheodorsson, ElvarTheodorsson, AnnetteStröm, Jakob

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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesCenter for DiagnosticsDivision of Microbiology and Molecular MedicineDepartment of NeurosurgeryDepartment of Clinical Chemistry
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