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Switchable bioelectronics
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-1815-9699
2016 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 76, 251-265 p.Article in journal (Refereed) Published
Abstract [en]

We review the rapidly emerging field of switchable interfaces and its implications for bioelectronics. We seek to piece together early breakthroughs and key developments, and highlight and discuss the future of switchable bioelectronics by focusing on bio-electrochemical processes based on mimicking and controlling biological environments with external stimuli. All these studies strive to answer a fundamental question: “how do living systems probe and respond to their surroundings? And, following on from that: “how one can transform these concepts to serve the practical world of bioelectronics?” The central obstacle to this vision is the absence of versatile interfaces that are able to control and regulate the means of communication between biological and electronic systems. Here, we review the overall progress made to date in building such interfaces at the level of individual biomolecules and focus on the latest efforts to generate device platforms that integrate bio-interfaces with electronics.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 76, 251-265 p.
Keyword [en]
Switchable bioelectronics, Stimuli-responsive bio-interface, Controllable catalysis
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:liu:diva-120983DOI: 10.1016/j.bios.2015.06.023ISI: 000364895000020PubMedID: 26139319OAI: oai:DiVA.org:liu-120983DiVA: diva2:850320
Available from: 2015-09-01 Created: 2015-09-01 Last updated: 2016-05-04Bibliographically approved
In thesis
1. Interfacing nanomaterials for bioelectronic applications
Open this publication in new window or tab >>Interfacing nanomaterials for bioelectronic applications
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The integration of nanomaterials between biological and electronic world has revolutionized the way of understanding how to generate functional bioelectronic device and open a new horizon for the future of bioelectronics. The use of nanomaterials as a versatile interface in the area of bioelectronics offers many practical solutions and recently outshines as an alternative method to overcome technical challenges to control and regulate the mean of communication between biological and electronics systems. Therefore, the interfacing nanomaterials yields broad platform of functional units for the integration as bioelectronic interfaces and starts to have a great importance to many fields within the life science.

In parallel with the advancements for the successful combination of biological and electronic worlds using nanotechnology in a conventional way, a new branch of switchable bioelectronics based on signal-responsive materials and related interfaces have been emerged. The switchable bioelectronics consists of functional interfaces equipped with molecular cue that able to mimic and adapt their natural environment and change physical and chemical properties on demand. These switchable interfaces are essential to develop a range of technologies to understand function and properties of biological systems such as bio-catalysis, control of ion transfer and molecular recognition used in bioelectronics systems.

This thesis focuses on both the integration of functional nanomaterials to improve electrical interfacing between biological system and electronics and also the generation of a dynamic interface having ability to respond real-life physical and chemical changes. The developing of such a dynamic interface allows one to understand how do living system probe and respond their changing environment and also help control and modulate bio-molecular interactions in a confined space using external physical and chemical stimuli. First, the integration of various nanomaterials is described to understand the effect of different surface modifications and morphologies using different materials on the basis of enzyme-based electrochemical sensing of biological analytes. Then, various switchable interfaces including temperature, light and pH, consist of graphene-enzyme and responsive polymer, are developed to control and regulate enzymebased biomolecular reactions. Finally, physically controlled programmable bio-interface which is described by “AND” and “OR” Boolean logic operations using two different stimuli on one electrode, is introduced. Together, the findings presented in this thesis lay the groundwork for the establishment switchable and programmable bioelectronics. The both approaches are promising candidates to provide key building blocks for future practical systems, as well as model systems for fundamental research.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2015. 76 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1684
National Category
Biochemistry and Molecular Biology Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-120990 (URN)10.3384/diss.diva-120990 (DOI)978-91-7519-028-0 (print) (ISBN)
Public defence
2015-09-07, Planck, Fysikhuset, Campus Valla, Linköping, 13:15 (English)
Opponent
Supervisors
Available from: 2015-09-01 Created: 2015-09-01 Last updated: 2016-06-07Bibliographically approved

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