Identification of the mechanical parameters for the human uterus in vivo using intrauterine pressure measurements
2016 (English)In: International Journal for Numerical Methods in Biomedical Engineering, ISSN 2040-7939, E-ISSN 2040-7947Article in journal (Refereed) Epub ahead of print
There are limited experimental data to characterize the mechanical response of human myometrium. A method is presented in this work to identify mechanical parameters describing the active response of human myometrium from the in vivo intrauterine pressure measurements. A finite element model is developed to compute the intrauterine pressure during labor in response to an increase in the intracellular calcium ion concentration within myometrial smooth muscle cells. The finite element model provides the opportunity to tune mechanical parameters in order to fit the computed intrauterine pressure to in vivo measurements. Since the model is computationally expensive, a cheaper meta-model is generated to approximate the model response. By fitting the meta-model response to the in vivo measurements, the parameters used to determine the active response of human myometrial smooth muscle are identified.
Place, publisher, year, edition, pages
John Wiley & Sons, 2016.
Intrauterine pressure, Response surface methodology, Parameter Identification, Meta-modeling
Applied Mechanics Mechanical Engineering
IdentifiersURN: urn:nbn:se:liu:diva-121014DOI: 10.1002/cnm.2778OAI: oai:DiVA.org:liu-121014DiVA: diva2:850823
At the time of the thesis presentation this publication was in status Manuscript.2015-09-022015-09-022016-04-13Bibliographically approved