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Characterization of a Surface Ag-AgCl Electrode using the Paxon Test Platform
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering. (Biomedical instrumentation and neural engineering)
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0002-0012-7867
2015 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Evaluation of an electrode for intraelectrode differences using both a traditional gain-phase method and the Paxon test platform. The direct gain-phase measurements are useful to extract the transfer function of the electrode, as well as some other base parameters. The Paxon test platform is a complementary method that tests electrodes under conditions that are more realistic than the gel-to-gel connection used in the gain-phase method. Testing stability over time e.g. DC signal drift (worst set 6,31 ± 43,00 nV) over a one hour of measurement duration was carried out. The Paxon also lets tests be performed beyond what the gain-phase methods can measure, for example electrode rotation, which would uncover variations in the symmetry of the electrode. When tested, the symmetry properties of the electrode (test set variations, start to end, over rotations 0,90,180 and 270 degrees) resulted in a peak to peak variation in detected amplitude of 5.3 ±8.9 mV. Intraelectrode variations were detected and quantized with the Paxon test platform.

Place, publisher, year, edition, pages
2015.
Keyword [en]
Electrode testing, Characterization, Coupling Parameters. Stability test, Axon potential
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-121087OAI: oai:DiVA.org:liu-121087DiVA: diva2:851637
Available from: 2015-09-07 Created: 2015-09-07 Last updated: 2016-05-04Bibliographically approved
In thesis
1. Action Potential Generator and Electrode Testing
Open this publication in new window or tab >>Action Potential Generator and Electrode Testing
2015 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

Design, validation and application of a test platform for electrode characterization and comparison is a problem today. Development of target specific electrodes is increasing, for example surface cloth electrodes, non-contact electrodes, and deep brain stimulation electrodes. Whenever these new designs are implemented, there is always a need for testing. How these tests should be performed to verify the function of the electrode in an environment like the one they are designed for is still not solved.

In this thesis, a physical axon, the Paxon, is suggested as a possibility to overcome this issue. The intent of the Paxon was to generate an electric field that is similar to the external field created by a live axonal process when an action potential is propagating along its length, and to do this in a stable, repeatable manner. In order to meet these specifications, the Paxon was designed with a microcontroller to drive the sequence of events and control the output parameters. A chamber with gold wire nodes entering through the bottom was manufactured as a dimensional mimic to a myelinated 20 μm diameter nerve axon segment. The chamber was flooded with normal saline solution mimicking the intervening tissues and to allow ionic coupling of electrodes to the electrical field produced in the chamber.

The initial validation tests demonstrated that the timing is stable (196.4 ± 0.06 ms between trigger to action potential), as is the output “detected” amplitude (1.5 ± 0.05 mV with a gain of 40).

Once the Paxon test platform was verified as functional for its intended application of testing electrodes for comparison, it was then used to compare a set of six electrodes (used as a set of three differential pairs) from a single manufacturer lot and batch number.

With this approach, better assessment of the stability of the  manufactured electrode, as well as longer term stability, can be attained. As more electrodes of similar and differing types are tested, the data can be used for inter-electrode comparisons and eventually verification of newelectrode designed.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2015. 44 p.
Series
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 1725
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-121088 (URN)978-91-7685-974-2 (print) (ISBN)
Presentation
2015-09-25, IMT 1, Campus US, Linköpings universitet, Linköping, 13:00 (Swedish)
Opponent
Supervisors
Note

The Series name Linköping Studies in Science and Technology Licentiate Thesis in the thesis is incorrect. The correct series name is Linköping Studies in Science and Technology. Thesis.

Available from: 2015-09-07 Created: 2015-09-07 Last updated: 2016-05-04Bibliographically approved

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Latorre, Malcolm A.Salerud, E. GöranWårdell, Karin
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