liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
NUCLEOSIDE ANALOG ACTIVITY IN MALIGNANT MELANOMA CELL LINES
Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Drug Research.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology.
2015 (English)In: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 34, no 9, 639-649 p.Article in journal (Refereed) Published
Abstract [en]

Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies. Screening malignant melanoma cell lines against NAs revealed high sensitivity to several of them. This was believed to be due to the high levels of dGK expression in these cells. Downregulation of dGK in the melanoma cell line RaH5 using siRNA did not cause resistance to NAs as expected, but instead cells became more sensitive. This was probably partly due to the increased activity of another mitochondrial enzyme, thymidine kinase 2, seen in transfected cells.

Place, publisher, year, edition, pages
Taylor andamp; Francis: STM, Behavioural Science and Public Health Titles , 2015. Vol. 34, no 9, 639-649 p.
Keyword [en]
Deoxyguanosine kinase; melanoma; leukemia; nucleoside analog; RNAi
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121095DOI: 10.1080/15257770.2015.1047029ISI: 000359601400004PubMedID: 26252632OAI: oai:DiVA.org:liu-121095DiVA: diva2:852016
Note

Funding Agencies|Swedish Cancer Foundation; County Council of Ostergotland; Swedish Medical Society; AFA Insurance; Swedish Fund for Research without Animal Experiments

Available from: 2015-09-07 Created: 2015-09-07 Last updated: 2016-03-23

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Fyrberg, AnnaLotfi, Kourosh
By organisation
Faculty of Medicine and Health SciencesDivision of Drug ResearchDepartment of Clinical Pharmacology
In the same journal
Nucleosides, Nucleotides & Nucleic Acids
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 43 hits
ReferencesLink to record
Permanent link

Direct link