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NGAL and cystatin C: two possible early markers of diabetic nephropathy in young patients with type 1 diabetes mellitus: one year follow up
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. University of Athens, Greece.
Aghia Sophia Childrens Hospital, Greece.
University of Athens, Greece.
Attikon Hospital, Greece.
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2015 (English)In: HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, ISSN 1109-3099, Vol. 14, no 2, 232-240 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Diabetic nephropathy constitutes a major long-term complication in patients with type 1 diabetes mellitus (T1D) and its diagnosis is based on microalbuminuria. The aim of this observational follow-up study was to explore the role of neutrophil-gelatinase-associated lipocalin (NGAL) and cystatin C in unravelling early diabetic nephropathy even in patients with normoalbuminuria.

DESIGN: Fifty-six euthyroid patients with T1D, with mean age 13.1 (SD: 3.2) years, and 49 healthy controls with mean age 12.8 (SD: 6.6) were recruited. Besides standard blood chemistry and urinary albumin excretion, serum NGAL (ELISA) and cystatin C (nephelometry) were measured at enrollment and after 12-15 months. GFR was calculated with the bedside Schwartz formula (eGFR) and the Lund strategy formula (L-eGFR).

RESULTS: At baseline, mean NGAL levels were not significantly different between children with diabetes and controls. At re-evaluation, mean NGAL value and mean eGFR value in patients with diabetes were increased (p=0.032 and p=0.003 respectively). At both baseline and reevaluation, NGAL was positively correlated with cystatin C (r=0.41, pless than0.001), systolic arterial pressure z-score (r=0.3, p=0.031) and creatinine (r=0.32, p=0.010). NGAL correlated negatively with eGFR (r=-0.26, p=0.049) and L-eGFR (r=-0.33, p=0.010). Cystatin C had a negative correlation to eGFR (r=-0.29, p=0.025) and a positive one with creatinine (r=0.35, p=0.009) at reevaluation. No statistically significant correlation was found between cystatin C and microalbuminuria (p=0.736).

CONCLUSIONS: NGAL and cystatin C, known markers of renal injury, correlate with renal function decline in T1D, suggesting that they may be used as supplementary tests to urine albumin excretion in order to unmask early renal dysfunction.

Place, publisher, year, edition, pages
HELLENIC ENDOCRINE SOC , 2015. Vol. 14, no 2, 232-240 p.
Keyword [en]
cystatin C; diabetes-induced nephropathy; NGAL; type 1 diabetes; youth
National Category
Endocrinology and Diabetes
URN: urn:nbn:se:liu:diva-121149DOI: 10.14310/horm.2002.1520ISI: 000358629900006PubMedID: 25402375OAI: diva2:852240
Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2016-01-07Bibliographically approved

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Endocrinology and Diabetes

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