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Editorial Material: Wipping p53 into subservience in B-cell development in BLOOD, vol 126, issue 5, pp 566-567
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2015 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 126, no 5, 566-567 p.Article in journal, Editorial material (Other academic) Published
Abstract [en]

In this issue of Blood, Yi et al reveal an important role for the protein phosphatase Wip1 (PPM1D) in the regulation of B-cell homeostasis.(1) Mice deficient in the Wip1 gene display increased apoptosis in the pre-B-cell compartment and a reduction in peripheral B-cell numbers, a phenotype exacerbated with age and upon serial transplantations of bone marrow (BM) cells. 1 Even though Wip1 has the ability to modulate multiple signaling pathways in the cell, the restoration of B-cell numbers upon deletion of the p53 gene(1) suggests that an autoregulatory loop between p53 and Wip1 is of importance to maintain normal production of B lymphocytes.

Place, publisher, year, edition, pages
AMER SOC HEMATOLOGY , 2015. Vol. 126, no 5, 566-567 p.
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-121139DOI: 10.1182/blood-2015-06-649475ISI: 000358871900003PubMedID: 26228168OAI: diva2:852270
Available from: 2015-09-08 Created: 2015-09-08 Last updated: 2016-04-24

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Sigvardsson, Mikael
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