Editorial Material: Wipping p53 into subservience in B-cell development in BLOOD, vol 126, issue 5, pp 566-567
2015 (English)In: Blood, ISSN 0006-4971, E-ISSN 1528-0020, Vol. 126, no 5, 566-567 p.Article in journal, Editorial material (Other academic) Published
In this issue of Blood, Yi et al reveal an important role for the protein phosphatase Wip1 (PPM1D) in the regulation of B-cell homeostasis.(1) Mice deficient in the Wip1 gene display increased apoptosis in the pre-B-cell compartment and a reduction in peripheral B-cell numbers, a phenotype exacerbated with age and upon serial transplantations of bone marrow (BM) cells. 1 Even though Wip1 has the ability to modulate multiple signaling pathways in the cell, the restoration of B-cell numbers upon deletion of the p53 gene(1) suggests that an autoregulatory loop between p53 and Wip1 is of importance to maintain normal production of B lymphocytes.
Place, publisher, year, edition, pages
AMER SOC HEMATOLOGY , 2015. Vol. 126, no 5, 566-567 p.
IdentifiersURN: urn:nbn:se:liu:diva-121139DOI: 10.1182/blood-2015-06-649475ISI: 000358871900003PubMedID: 26228168OAI: oai:DiVA.org:liu-121139DiVA: diva2:852270