Optical Estimation of Beta 2 Microglobulin during Hemodiafiltration - Does It Work?
2015 (English)In: Blood Purification, ISSN 0253-5068, E-ISSN 1421-9735, Vol. 40, no 2, 113-119 p.Article in journal (Refereed) Published
BACKGROUND: Currently, urea reduction seems to be the most widely used dialysis dose parameter. The aim of this study was to investigate the possibility to monitor beta 2-microglobulin (β2-M) elimination by utilizing the ultraviolet (UV) absorbance of spent dialysate.
METHODS: Blood and spent dialysate were collected during two week's sessions in 8 patients, one week in hemodialysis (HD) and one in hemodiafiltration (HDF). Correlation analysis between UV-wavelengths and concentrations of solutes in spent dialysate was performed. The reduction ratio (RR) of concentrations in blood, dialysate and UV-absorbance were compared.
RESULTS: Differences between HD and HDF were discovered in wavelength correlation maxima for the solutes. Relative error in RR (%) was larger (p < 0.05) for β2-M than for the other solutes. The most reasonable explanation is that β2-M does not absorb UV-radiation; instead, the absorbance of surrogate substances is measured.
CONCLUSION: A high correlation between UV-absorbance and β2-M can be achieved for HDF but not for HD. Still, UV-absorbance could perhaps be used in solely HDF mode for estimation of β2-M removal. © 2015 S. Karger AG, Basel.
Place, publisher, year, edition, pages
S. Karger, 2015. Vol. 40, no 2, 113-119 p.
IdentifiersURN: urn:nbn:se:liu:diva-121293DOI: 10.1159/000381797ISI: 000361154700003PubMedID: 26159848OAI: oai:DiVA.org:liu-121293DiVA: diva2:853428
Funding text: Estonian Science Foundation ; Estonian Ministry of Education and Research [IUT 19-2]; European Union through the European Regional Development Fund2015-09-142015-09-142015-10-07Bibliographically approved