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Optical Estimation of Beta 2 Microglobulin during Hemodiafiltration - Does It Work?
Region Östergötland, Heart and Medicine Center, Department of Nephrology. Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences.
Technomedicum, Tallinn University of Technology, Tallinn, Estonia.
Region Östergötland, Local Health Care Services in West Östergötland, Research & Development Unit in Local Health Care. Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Medicine and Health Sciences.
Region Östergötland, Heart and Medicine Center, Department of Nephrology. Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences.
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2015 (English)In: Blood Purification, ISSN 0253-5068, E-ISSN 1421-9735, Vol. 40, no 2, 113-119 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Currently, urea reduction seems to be the most widely used dialysis dose parameter. The aim of this study was to investigate the possibility to monitor beta 2-microglobulin (β2-M) elimination by utilizing the ultraviolet (UV) absorbance of spent dialysate.

METHODS: Blood and spent dialysate were collected during two week's sessions in 8 patients, one week in hemodialysis (HD) and one in hemodiafiltration (HDF). Correlation analysis between UV-wavelengths and concentrations of solutes in spent dialysate was performed. The reduction ratio (RR) of concentrations in blood, dialysate and UV-absorbance were compared.

RESULTS: Differences between HD and HDF were discovered in wavelength correlation maxima for the solutes. Relative error in RR (%) was larger (p < 0.05) for β2-M than for the other solutes. The most reasonable explanation is that β2-M does not absorb UV-radiation; instead, the absorbance of surrogate substances is measured.

CONCLUSION: A high correlation between UV-absorbance and β2-M can be achieved for HDF but not for HD. Still, UV-absorbance could perhaps be used in solely HDF mode for estimation of β2-M removal. © 2015 S. Karger AG, Basel.

Place, publisher, year, edition, pages
S. Karger, 2015. Vol. 40, no 2, 113-119 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121293DOI: 10.1159/000381797ISI: 000361154700003PubMedID: 26159848OAI: oai:DiVA.org:liu-121293DiVA: diva2:853428
Note

Funding text: Estonian Science Foundation [8621]; Estonian Ministry of Education and Research [IUT 19-2]; European Union through the European Regional Development Fund

Available from: 2015-09-14 Created: 2015-09-14 Last updated: 2015-10-07Bibliographically approved

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Uhlin, FredrikYngman-Uhlin, PiaFernström, Anders
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Department of NephrologyDivision of Nursing ScienceFaculty of Medicine and Health SciencesResearch & Development Unit in Local Health CareDivision of Drug Research
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Blood Purification
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