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Pain and activity limitations in women and men with contemporary treated early RA compared to 10 years ago: the Swedish TIRA project
School of Health Sciences, Jönköping University, Jönköping, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Rheumatology.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. School of Health Sciences, Jönköping University, Jönköping, Sweden; School of Occupational Therapy and Social Work, CHIRI, Curtin University, Perth, WA, Australia.
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, The Swedish Institute for Disability Research.
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2015 (English)In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 44, no 4, 259-264 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To study differences regarding pain and activity limitations during the 3 years following diagnosis in women and men with contemporary treated early RA compared with their counterparts who were diagnosed 10 years earlier. Method: This study was based on patients recruited to the Early Intervention in RA (TIRA) project. In the first cohort (TIRA-1) 320 patients were included in time for diagnosis during 1996-1998 and 463 patients were included in the second cohort (TIRA-2) during 2006-2009. Disease activity, pain intensity (Visual Analogue Scale, VAS), bodily pain (BP) in the 36-item Short Form Health Survey (SF-36), activity limitations (Health Assessment Questionnaire, HAQ), and medication were reported at inclusion and at follow-up after 1, 2, and 3 years. Results: Disease activity, pain, and activity limitations were pronounced at inclusion across both genders and in both cohorts, with some improvement observed during the first year after diagnosis. Disease activity did not differ between cohorts at inclusion but was significantly lower at the follow-ups in the TIRA-2 cohort, in which the patients were prescribed traditional disease-modifying anti-rheumatic drugs (DMARDs) and biological agents more frequently. In TIRA-2, patients reported significantly lower pain and activity limitations at all follow-ups, with men reporting lower pain than women. Women reported significantly higher activity limitations at all time points in TIRA-2. Conclusions: Pain and activity limitations were still pronounced in the contemporary treated early RA cohort compared with their counterparts diagnosed 10 years earlier and both of these factors need to be addressed in clinical settings.

Place, publisher, year, edition, pages
Informa Healthcare , 2015. Vol. 44, no 4, 259-264 p.
National Category
Basic Medicine
URN: urn:nbn:se:liu:diva-121326DOI: 10.3109/03009742.2014.997285ISI: 000359960100001PubMedID: 25786818OAI: diva2:853658

Funding Agencies|Medical Research Council of Southeast Sweden (FORSS); Academy for Health and Care Jonkoping County Council (Futurum)

Available from: 2015-09-14 Created: 2015-09-14 Last updated: 2015-10-01Bibliographically approved

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Thyberg, IngridFalkmer, TorbjörnDahlström, ÖrjanBjörk, Mathilda
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of RheumatologyDivision of Community MedicinePain and Rehabilitation CenterDisability ResearchFaculty of Arts and SciencesThe Swedish Institute for Disability ResearchDepartment of Clinical and Experimental MedicineRehabilitation Center
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