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The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland.
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2015 (English)In: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol. 6, no 30, 29753--29770 p.Article in journal (Refereed) Published
Abstract [en]

Induced pluripotent stem cells (iPS) have become crucial in medicine and biology. Several studies indicate their phenotypic similarities with cancer stem cells (CSCs) and a propensity to form tumors. Thus it is desirable to identify a trait which differentiates iPS populations and CSCs. Searching for such a feature, in this work we compare the restriction (R) point-governed regulation of cell cycle progression in different cell types (iPS, cancer, CSC and normal cells) based on the expression profile of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1). Our study reveals that PFKFB3 and PFK1 expression allows discrimination between iPS and CSCs. Moreover, cancer and iPS cells, when cultured under hypoxic conditions, alter their expression level of PFKFB3 and PFK1 to resemble those in CSCs. We also observed cell type-related differences in response to inhibition of PFKFB3. This possibility to distinguish CSC from iPS cells or non-stem cancer cells by PFKB3 and PFK1 expression improves the outlook for clinical application of stem cell-based therapies and for more precise detection of CSCs.

Place, publisher, year, edition, pages
Albany, NY, USA: Impact Journals LLC , 2015. Vol. 6, no 30, 29753--29770 p.
Keyword [en]
PFKFB3; R-point; cancer stem cells; induced pluripotent stem cells
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-121349DOI: 10.18632/oncotarget.4995ISI: 000363183200098PubMedID: 26337471OAI: oai:DiVA.org:liu-121349DiVA: diva2:853739
Available from: 2015-09-14 Created: 2015-09-14 Last updated: 2017-12-05Bibliographically approved

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Cieślar-Pobuda, ArturVilas Jain, MayurKratz, GunnarWiechec, Emilia

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Division of Cell BiologyFaculty of Medicine and Health SciencesDivision of Clinical SciencesDepartment of Hand and Plastic SurgeryDivision of Neuro and Inflammation Science
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