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A Miniature Graphene-based Biosensor for Intracellular Glucose Measurements
Linköping University, Department of Science and Technology. Linköping University, Faculty of Science & Engineering. CESAT, Islamabad, Pakistan.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology. COMSATS Institute Informat Technology, Lahore, Pakistan.
COMSATS Institute Informat Technology, Lahore, Pakistan.
Acreo AB, Norrköping, Sweden.
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2015 (English)In: Electrochimica Acta, ISSN 0013-4686, E-ISSN 0019-4686, Vol. 174, 574-580 p.Article in journal (Refereed) Published
Abstract [en]

We report on a small and simple graphene-based potentiometric sensor for the measurement of intracellular glucose concentration. A fine borosilicate glass capillary coated with graphene and subsequently immobilized with glucose oxidase (GOD) enzyme is inserted into the intracellular environment of a single human cell. The functional groups on the edge plane of graphene assist the attachment with the free amine terminals of GOD enzyme, resulting in a better immobilization. The sensor exhibits a glucose-dependent electrochemical potential against an Ag/AgCl reference microelectrode which is linear across the whole concentration range of interest (10 - 1000 mu M). Glucose concentration in human fat cell measured by our graphene-based sensor is in good agreement with nuclear magnetic resonance (NMR) spectroscopy.

Place, publisher, year, edition, pages
Elsevier , 2015. Vol. 174, 574-580 p.
Keyword [en]
Graphene; Bio-sensors; Glucose-oxidase; Intracellular sensors; Graphene oxide; Glucose Sensor
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121309DOI: 10.1016/j.electacta.2015.06.035ISI: 000359873400073OAI: oai:DiVA.org:liu-121309DiVA: diva2:854244
Available from: 2015-09-16 Created: 2015-09-14 Last updated: 2015-10-02Bibliographically approved

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ul Hasan, KamranAsif, MuhammadNour, OmerWillander, MagnusFagerholm, SiriStrålfors, Peter
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Department of Science and TechnologyFaculty of Science & EngineeringThe Institute of TechnologyPhysics and ElectronicsDivision of Cell BiologyFaculty of Medicine and Health Sciences
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Electrochimica Acta
Electrical Engineering, Electronic Engineering, Information EngineeringClinical Medicine

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