Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitability
2015 (English)In: Scientific Reports, ISSN 2045-2322, Vol. 5, no 13278Article in journal (Refereed) Published
Voltage-gated ion channels generate cellular excitability, cause diseases when mutated, and act as drug targets in hyperexcitability diseases, such as epilepsy, cardiac arrhythmia and pain. Unfortunately, many patients do not satisfactorily respond to the present-day drugs. We found that the naturally occurring resin acid dehydroabietic acid (DHAA) is a potent opener of a voltage-gated K channel and thereby a potential suppressor of cellular excitability. DHAA acts via a non-traditional mechanism, by electrostatically activating the voltage-sensor domain, rather than directly targeting the ion-conducting pore domain. By systematic iterative modifications of DHAA we synthesized 71 derivatives and found 32 compounds more potent than DHAA. The most potent compound, Compound 77, is 240 times more efficient than DHAA in opening a K channel. This and other potent compounds reduced excitability in dorsal root ganglion neurons, suggesting that resin-acid derivatives can become the first members of a new family of drugs with the potential for treatment of hyperexcitability diseases.
Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Journals - Option C / Nature Publishing Group , 2015. Vol. 5, no 13278
Clinical Medicine Chemical Sciences
IdentifiersURN: urn:nbn:se:liu:diva-121307DOI: 10.1038/srep13278ISI: 000359905300001PubMedID: 26299574OAI: oai:DiVA.org:liu-121307DiVA: diva2:854293
Funding Agencies|Swedish Research Council; Swedish Brain Foundation; Swedish Heart-Lung Foundation; ALF; County Council of Ostergotland2015-09-162015-09-142015-10-02Bibliographically approved