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Prognostic significance of high hyperdiploid and triploid/tetraploid adult acute myeloid leukemia
Skåne University Hospital, Sweden; Lund University, Sweden.
Skåne University Hospital, Sweden.
Skåne University Hospital, Sweden; Lund University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology. Linköping University, Faculty of Medicine and Health Sciences.
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2015 (English)In: American Journal of Hematology, ISSN 0361-8609, E-ISSN 1096-8652, Vol. 90, no 9, 800-805 p.Article in journal (Refereed) Published
Abstract [en]

To ascertain the clinical implications of high hyperdiploid (HH; 49-65 chromosomes) and triploid/tetraploid (TT; greater than65 chromosomes) adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Of the 3,654 cytogenetically informative cases diagnosed between January 1997 and May 2014, 68 (1.9%) were HH (n=50)/TT (n=18). Patients with HH/TT were older than those with intermediate risk (IR) AML (median 71 years vs. 67 years; P=0.042) and less often had de novo AML (63% vs. 79%; P=0.004); no such differences were observed between HH/TT and complex karyotype (CK) AML. The overall survival (OS) was similar between patients with HH/TT and CK AML (median 0.9 years vs. 0.6 years; P=0.082), whereas OS was significantly longer (median 1.6 years; P=0.028) for IR AML. The OS was shorter for cases with HH than with TT (median 0.6 years vs. 1.4 years; P=0.032) and for HH/TT AMLs with adverse abnormalities (median 0.8 years vs. 1.1 years; P=0.044). In conclusion, HH/TT AML is associated with a poor outcome, but chromosome numbers greater than65 and absence of adverse aberrations seem to translate into a more favorable prognosis. Thus, HH/TT AMLs are clinically heterogeneous and should not automatically be grouped as high risk.Am. J. Hematol. 90:800-805, 2015. (c) 2015 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2015. Vol. 90, no 9, 800-805 p.
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URN: urn:nbn:se:liu:diva-121425DOI: 10.1002/ajh.24091ISI: 000360218000023PubMedID: 26088289OAI: diva2:855143

Funding Agencies|Swedish Cancer Society; Swedish Research Council; Regional Cancer Centers; Swedish Association of Local Authorities and Regions (SKL); Governmental Funding of Clinical Research within the National Health Service

Available from: 2015-09-18 Created: 2015-09-18 Last updated: 2016-04-11

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Antunovic, Petar
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Division of Clinical SciencesDepartment of HaematologyFaculty of Medicine and Health Sciences
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