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Impact of vaccination on the molecular epidemiology and evolution of group A rotaviruses in Latin America and factors affecting vaccine efficacy
National Autonomous University of Leon, Nicaragua.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
2015 (English)In: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 34, 106-113 p.Article, review/survey (Refereed) Published
Abstract [en]

Despite high rotavirus (RV) vaccine coverage (similar to 83%) and good effectiveness (similar to 77%) against RV-diarrhea hospitalization, RV is still contributing to the burden of diarrhea that persists in hospital settings in several Latin American countries, where RV vaccination is being implemented. Due to the extensive genomic and antigenic diversity, among co-circulating human RV, a major concern has been that the introduction of RV vaccination could exert selection pressure leading to higher prevalence of strains not included in the vaccines and/or emergence of new strains, thus, reducing the efficacy of vaccination. Here we review the molecular epidemiology of RV in Latin America and explore issues of RV evolution and selection in light of vaccination. We further explore etiologies behind the large burden of diarrhea remaining after vaccination in some countries and discuss plausible reasons for vaccine failures. (C) 2015 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2015. Vol. 34, 106-113 p.
Keyword [en]
Rotavirus; Vaccination; Antigenic sites; Gene reassortment; Host genetics; Molecular epidemiology; Latin America
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121761DOI: 10.1016/j.meegid.2015.06.013ISI: 000360902400014PubMedID: 26079278OAI: oai:DiVA.org:liu-121761DiVA: diva2:859356
Available from: 2015-10-06 Created: 2015-10-05 Last updated: 2015-10-06

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Nordgren, Johan
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Division of Microbiology and Molecular MedicineFaculty of Medicine and Health Sciences
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