liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Prognostic Significance of Resting Heart Rate and Use of beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction Findings From the Swedish Heart Failure Registry
Ostra Hospital, Sweden; Chinese Peoples Liberat Army Gen Hospital, Peoples R China.
Karolinska University Hospital, Sweden; Karolinska Institute, Sweden.
Karolinska Institute, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.ORCID iD: 0000-0001-6353-8041
Show others and affiliations
2015 (English)In: Circulation Heart Failure, ISSN 1941-3289, E-ISSN 1941-3297, Vol. 8, no 5, 871-879 p.Article in journal (Refereed) Published
Abstract [en]

Background In heart failure and reduced ejection fraction, the prognostic role of heart rate (HR) in atrial fibrillation (AF) is unknown and the effectiveness of -blockers has recently been questioned in AF. Methods and Results A total of 18 858 patients with heart failure and reduced ejection fraction registered with Swedish Heart Failure Registry were included in this study: patients with sinus rhythm (SR; n=11 466) and patients with AF (n=7392). The outcome measure was all-cause mortality. Compared with HR 60 beats per minute, the adjusted hazard ratios for mortality in SR were 1.26 for HR=61 to 70 beats per minute, 1.37 for HR=71 to 80 beats per minute, 1.52 for HR=81 to 90 beats per minute, 1.63 for HR=91 to 100 beats per minute, and 2.69 for HR greater than100 beats per minute. However, in AF, the hazard ratio increased only for HR greater than100 beats per minute (1.30; P=0.001). -blocker use was associated with reduced mortality in SR (hazard ratio, 0.77; P=0.011) and in AF (hazard ratio, 071; Pless than0.001). For -blocker use in SR, the hazard ratio gradually increased with HR increment, whereas in AF, the hazard ratio significantly increased only for HR greater than100 beats per minute (1.29; P=0.003) compared with HR 60 beats per minute. Conclusions In patients with heart failure and reduced ejection fraction, a higher HR was associated with increased mortality in SR, but in AF, this is true only for HR greater than100 beats per minute. -blocker use was associated with reduced mortality both in SR and in AF.

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS and WILKINS , 2015. Vol. 8, no 5, 871-879 p.
Keyword [en]
atrial fibrillation; heart failure; heart rate; mortality; registries
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-121900DOI: 10.1161/CIRCHEARTFAILURE.115.002285ISI: 000361186000006PubMedID: 26243796OAI: oai:DiVA.org:liu-121900DiVA: diva2:860756
Note

Funding Agencies|Swedish National Board of Health and Welfare; Swedish Association of Local Authorities and Regions; Swedish Society of Cardiology; Swedish Heart-Lung Foundation

Available from: 2015-10-13 Created: 2015-10-12 Last updated: 2015-10-13

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Dahlström, Ulf
By organisation
Division of Cardiovascular MedicineFaculty of Medicine and Health SciencesDepartment of Cardiology in Linköping
In the same journal
Circulation Heart Failure
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 47 hits
ReferencesLink to record
Permanent link

Direct link