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Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimers Disease: The NF-kappa B Connection
Banaras Hindu University, India.
Postgrad Institute Medical Educ and Research, India.
ICARE Institute Medical Science Research, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
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2015 (English)In: Current Topics in Medicinal Chemistry, ISSN 1568-0266, E-ISSN 1873-4294, Vol. 15, no 5, 446-457 p.Article, review/survey (Refereed) Published
Abstract [en]

Oxidative stress and inflammatory response are important elements of Alzheimers disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-kappa B and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-kappa B signaling cascade has been discussed in the end.

Place, publisher, year, edition, pages
BENTHAM SCIENCE PUBL LTD , 2015. Vol. 15, no 5, 446-457 p.
Keyword [en]
Alzheimers disease; Amyloid beta; Cytokines; NF-kappa B; Oxidative stress; Redox signaling
National Category
Basic Medicine
URN: urn:nbn:se:liu:diva-122123DOI: 10.2174/1568026615666150114160543ISI: 000361657500004OAI: diva2:861766
Available from: 2015-10-19 Created: 2015-10-19 Last updated: 2015-11-26

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The full text will be freely available from 2016-11-01 00:00
Available from 2016-11-01 00:00

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Sinha, Maitrayee Sardar
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
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