liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimers Disease: The NF-kappa B Connection
Banaras Hindu University, India.
Postgrad Institute Medical Educ and Research, India.
ICARE Institute Medical Science Research, India.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Show others and affiliations
2015 (English)In: Current Topics in Medicinal Chemistry, ISSN 1568-0266, E-ISSN 1873-4294, Vol. 15, no 5, 446-457 p.Article, review/survey (Refereed) Published
Abstract [en]

Oxidative stress and inflammatory response are important elements of Alzheimers disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-kappa B and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-kappa B signaling cascade has been discussed in the end.

Place, publisher, year, edition, pages
BENTHAM SCIENCE PUBL LTD , 2015. Vol. 15, no 5, 446-457 p.
Keyword [en]
Alzheimers disease; Amyloid beta; Cytokines; NF-kappa B; Oxidative stress; Redox signaling
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-122123DOI: 10.2174/1568026615666150114160543ISI: 000361657500004OAI: oai:DiVA.org:liu-122123DiVA: diva2:861766
Available from: 2015-10-19 Created: 2015-10-19 Last updated: 2015-11-26

Open Access in DiVA

The full text will be freely available from 2016-11-01 00:00
Available from 2016-11-01 00:00

Other links

Publisher's full text

Search in DiVA

By author/editor
Sinha, Maitrayee Sardar
By organisation
Division of Neuro and Inflammation ScienceFaculty of Medicine and Health Sciences
In the same journal
Current Topics in Medicinal Chemistry
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 53 hits
ReferencesLink to record
Permanent link

Direct link