Nanodosimetry and RBE values in radiotherapy
2015 (English)In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 166, no 1-4, 339-342 p.Article in journal (Refereed) Published
In a recent paper, the authors reported that the dose mean lineal energy, (y) over bar (D) in a volume of about 10-15 nm is approximately proportional to the alpha-parameter in the linear-quadratic relation used in fractionated radiotherapy in both low- and high-LET beams. This was concluded after analyses of reported radiation weighting factors, W-isoE (clinical RBE values), and (y) over bar (D) values in a large range of volumes. Usually, microdosimetry measurements in the nanometer range are difficult; therefore, model calculations become necessary. In this paper, the authors discuss the calculation method. A combination of condensed history Monte Carlo and track structure techniques for calculation of mean lineal energy values turned out to be quite useful. Briefly, the method consists in weighting the relative dose fractions of the primary and secondary charged particles with their respective energy-dependent dose mean lineal energies. The latter were obtained using a large database of Monte Carlo track structure calculations.
Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2015. Vol. 166, no 1-4, 339-342 p.
IdentifiersURN: urn:nbn:se:liu:diva-122120DOI: 10.1093/rpd/ncv196ISI: 000361806600069PubMedID: 25953788OAI: oai:DiVA.org:liu-122120DiVA: diva2:861770
Funding Agencies|Swedish Radiation Safety Authority (SSM); Karolinska Institutet (KI)2015-10-192015-10-192015-10-19