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Nanodosimetry and RBE values in radiotherapy
Karolinska Institute, Sweden.
RaySearch Labs, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Swedish Radiat Safety Author, Sweden.
Karolinska Institute, Sweden.
2015 (English)In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 166, no 1-4, 339-342 p.Article in journal (Refereed) Published
Abstract [en]

In a recent paper, the authors reported that the dose mean lineal energy, (y) over bar (D) in a volume of about 10-15 nm is approximately proportional to the alpha-parameter in the linear-quadratic relation used in fractionated radiotherapy in both low- and high-LET beams. This was concluded after analyses of reported radiation weighting factors, W-isoE (clinical RBE values), and (y) over bar (D) values in a large range of volumes. Usually, microdosimetry measurements in the nanometer range are difficult; therefore, model calculations become necessary. In this paper, the authors discuss the calculation method. A combination of condensed history Monte Carlo and track structure techniques for calculation of mean lineal energy values turned out to be quite useful. Briefly, the method consists in weighting the relative dose fractions of the primary and secondary charged particles with their respective energy-dependent dose mean lineal energies. The latter were obtained using a large database of Monte Carlo track structure calculations.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2015. Vol. 166, no 1-4, 339-342 p.
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-122120DOI: 10.1093/rpd/ncv196ISI: 000361806600069PubMedID: 25953788OAI: oai:DiVA.org:liu-122120DiVA: diva2:861770
Note

Funding Agencies|Swedish Radiation Safety Authority (SSM); Karolinska Institutet (KI)

Available from: 2015-10-19 Created: 2015-10-19 Last updated: 2015-10-19

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Carlsson Tedgren, Åsa
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Division of Radiological SciencesFaculty of Medicine and Health SciencesDepartment of Radiation Physics
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