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Low risk of seroconversion or clinical disease in humans after a bite by an Anaplasma phagocytophilum-infected tick
Ryhov County Hospital, Jönköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Ryhov County Hospital, Jönköping.
Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology.
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2015 (English)In: Ticks and Tick-borne Diseases, ISSN 1877-959X, E-ISSN 1877-9603, Vol. 6, no 6, 787-792 p.Article in journal (Refereed) Published
Abstract [en]

The risk of contracting human granulocytic anaplasmosis (HGA) after a tick bite is mainly unknown. In this study we investigated the clinical and serological response in 30 humans bitten by ticks positive for Anaplasma phagocytophilum (Group A), 30 humans bitten by Borrelia burgdorferi sensu lato (s.l.)-positive ticks (Group B), and 30 humans bitten by ticks negative for both A. phagocytophilum and B. burgdorferi s.l. (Group C). Ticks, blood samples and questionnaires were collected from tick-bitten humans at 34 primary healthcare centres in Sweden and in the Åland Islands, Finland, at the time of the tick bite and after three months. A total of 2553 ticks detached from humans in 2007-2009 were analyzed by polymerase chain reaction, and 31 (1.2%) were positive for A. phagocytophilum, 556 (21.8%) were positive for B. burgdorferi s.l., and eight (0.3%) were co-infected by A. phagocytophilum and B. burgdorferi s.l. The overall prevalence of Anaplasma IgG antibodies in the included participants (n=90) was 17%, and there was no significant difference between the groups A-C. Only one of the participants (in Group C) showed a four-fold increase of IgG antibodies against A. phagocytophilum at the three-month follow-up, but reported no symptoms. The frequency of reported symptoms did not differ between groups A-C, and was unrelated to the findings of A. phagocytophilum and B. burgdorferi s.l. in the detached ticks. We conclude that the risk for HGA or asymptomatic seroconversion after a tick bite in Sweden or in the Åland Islands is low, even if the tick is infected by A. phagocytophilum.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 6, no 6, 787-792 p.
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:liu:diva-122245DOI: 10.1016/j.ttbdis.2015.07.005ISI: 000362143800015PubMedID: 26187418OAI: oai:DiVA.org:liu-122245DiVA: diva2:864174
Note

Funding text: Swedish Research Council; Medical Research Council of Southeast Sweden (FORSS); Futurum Academy of Healthcare; Jonkoping County Council; Interreg IV A Programme ScandTick; Division of Medical Services, Ryhov County Hospital, Jonkoping

Available from: 2015-10-26 Created: 2015-10-26 Last updated: 2017-12-01

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Wilhelmsson, PeterKozak Ljunggren, MonikaLindgren, Per-EricForsberg, Pia

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Ticks and Tick-borne Diseases
Microbiology in the medical area

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