A variety of thiophene based ligands for detection of protein aggregates by surface plasmon resonance
(English)Manuscript (preprint) (Other academic)
By attaching an azide functional group via a tetraethylene glycol linker to the α-terminal position of a variety of oligothiophenes, thiophene-based ligands that can be utilized for detection of protein aggregates with surface plasmon resonance have been developed. All ligands displayed selectivity towards recombinant amyloid fibrils and the LCO/protein aggregate interaction could be detected by fluorescence as well as by surface plasmon resonance.
IdentifiersURN: urn:nbn:se:liu:diva-122274OAI: oai:DiVA.org:liu-122274DiVA: diva2:865141