Genetical Genomics of Behavior: A novel chicken genomic model for anxiety behavior
2016 (English)In: Genetics, ISSN 0016-6731, Vol. 202, no 1, 327+- p.Article in journal (Refereed) Published
The identification of genetic variants responsible for behavioral variation is an enduring goal in biology, with wide-scale ramifications, ranging from medical research to evolutionary theory on personality syndromes. Here, we use for the first time a large-scale genetical genomics analysis in the brain of the chicken to identify genes affecting anxiety as measured by an open field test. We combine quantitative trait locus (QTL) analysis in 572 individuals and expression QTL (eQTL) analysis in 129 individuals from an advanced intercross between domestic chickens and Red Junglefowl. We identify ten putative quantitative trait genes affecting anxiety behavior. These genes were tested for an association in the mouse Heterogenous Stock anxiety (open field) dataset and human GWAS datasets for bipolar disorder, major depressive disorder and schizophrenia. Although comparisons between species are complex, associations were observed for four of the candidate genes in mouse, and three of the candidate genes in humans. Using a multi-model approach we have therefore identified a number of putative quantitative trait genes affecting anxiety behavior, principally in the chicken but also with some potentially translational effects as well. This study demonstrates that the chicken is an excellent model organism for the genetic dissection of behavior.
Place, publisher, year, edition, pages
The Genetics Society, 2016. Vol. 202, no 1, 327+- p.
Anxiety, behavioral genes, eQTL, QTL, causal genes, personality
IdentifiersURN: urn:nbn:se:liu:diva-122276DOI: 10.1534/genetics.115.179010ISI: 000367718100026PubMedID: 26733665OAI: oai:DiVA.org:liu-122276DiVA: diva2:865181
Funding agencies: Swedish Research Council; Swedish Research Council for Environment; Agricultural Sciences and Spatial Planning; European Research Council [GENEWELL 322206]2015-10-272015-10-272016-02-01Bibliographically approved