Developmental and Epigenetic Origins of Male Reproductive Pathologies
2015 (English)In: The Epigenome and Developmental Origins of Health and Disease / [ed] Cheryl Rosenfeld, Elsevier, 2015, 1, 171-189 p.Chapter in book (Refereed)
Transgenerational epigenetic inheritance has gained increased attention due to the possibility that exposure to environmental toxicants or other stressors can induce long-lasting changes in lineages of organisms. The mechanism involves exposure of pregnant females and induction of germline epigenetic alterations in their developing embryos. This early developmental exposure generates phenotypic alterations in the adults. The germline epigenomic changes produced are then transmitted to future generations and associate with disease phenotypes in the unexposed individuals of subsequent generations. Exposures to environmental toxicants such as fungicides, pesticides, or plastic compounds have been shown in rodents to produce abnormal reproductive or metabolic phenotypes that are transgenerationally transmitted. These include transgenerational increases in the incidence of obesity, polycystic ovary syndrome (PCOS)-like symptoms, pregnancy defects, or germ cell apoptosis. Importantly, the increased incidence of these transgenerationally transmitted diseases in response to environmental exposures in animal models is sometimes drastic. The current evidence on transgenerational epigenetic inheritance observed in animal models allows predicting that environmental exposures of today's inhabitants of the world may affect the incidence of noninfectious diseases in future generations, which would be correlated with long-lasting alterations in the epigenome. The present chapter summarizes the evidence to date for transgenerational epigenetic inheritance, in both humans and animal models.
Place, publisher, year, edition, pages
Elsevier, 2015, 1. 171-189 p.
Development; DNA methylation; DOHaD; Epigenetics; Germline; Noncommunicable diseases; Transgenerational epigenetic inheritance
Biological Sciences Cell Biology Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:liu:diva-122303DOI: 10.1016/B978-0-12-801383-0.00021-9ISBN: 978-0-12-801383-0OAI: oai:DiVA.org:liu-122303DiVA: diva2:865537