The clinical presentation of celiac disease in 1030 Swedish children: changing features over the past 41 years: a long-term follow-up study
2016 (English)In: Digestive and Liver Disease, ISSN 1590-8658, E-ISSN 1878-3562, Vol. 48, no 1, 16-22 p.Article in journal (Refereed) Published
The features of pediatric celiac disease have changed in recent decades. We hypothesized that the age at diagnosis continued to increase, whereas the severity of symptoms should decrease.
In the present study, filed data about 1030 pediatric patients diagnosed with celiac disease between 1973 and 2013 were analysed. Available information covered 99.8% of the small bowel biopsies, and included information on sex, age, and clinical symptoms.
The age at diagnosis increased significantly, from a mean of 2.2 years during the first 10 years to 8.2 years the current years. The proportion of children with severe symptoms declined from 92.8% to 78%, as did the proportion of biopsies characterized by severe pathology. In recent years, the monosymptomatic form of celiac disease has been more common, and the number of patients detected at screening has increased. The frequency of patients with gastrointestinal symptoms, extra-intestinal symptoms, and failure to thrive and/or short stature at presentation decreased.
The mean age of newly diagnosed patients increased the last 15 years. Currently celiac disease shows a less severe picture in terms of symptoms and intestinal pathology. Younger children suffer primarily from gastrointestinal symptoms and growth failure, and adolescents from extra-intestinal manifestations.
Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 48, no 1, 16-22 p.
Clinical Medicine Microbiology in the medical area
IdentifiersURN: urn:nbn:se:liu:diva-122369DOI: 10.1016/j.dld.2015.09.018ISI: 000368761300004OAI: oai:DiVA.org:liu-122369DiVA: diva2:865974
Funding agencies: Medical Research Council of Southeast Sweden; County Council of Ostergotland; Swedish Research Council2015-10-302015-10-302016-02-24Bibliographically approved