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Frequent and long-term follow-up of health-related quality of life following allogeneic haematopoietic stem cell transplantation
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Haematology.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology.
Region Östergötland, Center for Health and Developmental Care, Regional Cancer Center South East Sweden.
Lund University, Sweden; Lund University, Sweden.
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2015 (English)In: European Journal of Cancer Care, ISSN 0961-5423, E-ISSN 1365-2354, Vol. 24, no 6, 898-910 p.Article in journal (Refereed) Published
Abstract [en]

Health-related quality of life (HRQL) was evaluated in 94 patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative (MAC, n=18) or reduced intensity conditioning (RIC, n=76). HRQL was assessed with the EORTC QLQ C-30 during the inpatient period as well as during the following 3years, i.e. at baseline and 12 times thereafter. Functional status and global quality of life decreased from baseline to weeks 2 and 3, especially role and social functions. Symptoms increased significantly during the first 3weeks, particularly appetite loss, nausea and vomiting, diarrhoea and fatigue. It took at least 1year for HRQL to return to the baseline level. The only function that improved significantly 3years after HSCT was role function. Patients treated with MAC experienced significantly worse HRQL at baseline than patients treated with RIC, as well as more pain, sleep disturbance and appetite loss in weeks 3 and 4. Patients with extensive chronic graft-versus-host disease experienced reduced HRQL. These results provide a clinically useful overview of patients HRQL during and after HSCT and indicate when they require increased support. The results demonstrate the importance of close follow-ups during the first year after HSCT to improve preventive or supportive interventions.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015. Vol. 24, no 6, 898-910 p.
Keyword [en]
quality of life; symptom; stem cell transplantation
National Category
Cancer and Oncology Hematology
Identifiers
URN: urn:nbn:se:liu:diva-122649DOI: 10.1111/ecc.12350ISI: 000363466200014PubMedID: 26156141OAI: oai:DiVA.org:liu-122649DiVA: diva2:871757
Available from: 2015-11-16 Created: 2015-11-13 Last updated: 2017-12-01Bibliographically approved

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Lotfi, KouroshBörjeson, Sussanne

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Lotfi, KouroshBörjeson, Sussanne
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDepartment of HaematologyDivision of Drug ResearchDepartment of Clinical PharmacologyRegional Cancer Center South East SwedenDivision of Nursing ScienceDepartment of Oncology
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European Journal of Cancer Care
Cancer and OncologyHematology

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