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Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. National Academic Medical Science Ukraine, Ukraine.
National Academic Medical Science Ukraine, Ukraine.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden. (Integrat Regenerat Med Ctr)
National Academic Medical Science Ukraine, Ukraine.
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2015 (English)In: Clinical and Translational Science, ISSN 1752-8054, E-ISSN 1752-8062, Vol. 8, no 5, 558-562 p.Article in journal (Refereed) Published
Abstract [en]

Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2015. Vol. 8, no 5, 558-562 p.
Keyword [en]
collagen; epithelium; grafting; patients; remodeling; transplantation
National Category
Other Basic Medicine
Identifiers
URN: urn:nbn:se:liu:diva-122789DOI: 10.1111/cts.12293ISI: 000363652100024PubMedID: 25996570OAI: oai:DiVA.org:liu-122789DiVA: diva2:873324
Note

Funding Agencies|Swedish Research Council (EU Nanomedicine project "I-CARE") [521-2012-5706]; Integrative Regenerative Medicine Centre, Linkoping, Sweden; Swedish Institute fellowship

Available from: 2015-11-23 Created: 2015-11-23 Last updated: 2017-12-01

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Buznyk, OleksiyIslam, Mohammad MirazulFagerholm, PerGriffith, May

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Buznyk, OleksiyIslam, Mohammad MirazulFagerholm, PerGriffith, May
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Division of Cell BiologyFaculty of Medicine and Health SciencesDivision of Neuro and Inflammation ScienceDepartment of Ophthalmology in Linköping
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