Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients
2015 (English)In: Clinical and Translational Science, ISSN 1752-8054, E-ISSN 1752-8062, Vol. 8, no 5, 558-562 p.Article in journal (Refereed) Published
Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.
Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2015. Vol. 8, no 5, 558-562 p.
collagen; epithelium; grafting; patients; remodeling; transplantation
Other Basic Medicine
IdentifiersURN: urn:nbn:se:liu:diva-122789DOI: 10.1111/cts.12293ISI: 000363652100024PubMedID: 25996570OAI: oai:DiVA.org:liu-122789DiVA: diva2:873324
Funding Agencies|Swedish Research Council (EU Nanomedicine project "I-CARE") [521-2012-5706]; Integrative Regenerative Medicine Centre, Linkoping, Sweden; Swedish Institute fellowship2015-11-232015-11-232016-04-12