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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, Faculty of Science & Engineering.
University of Calif San Diego, CA 92093 USA.
Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
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2015 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 21, no 43, 15133-15137 p.Article in journal (Refereed) Published
Abstract [en]

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2015. Vol. 21, no 43, 15133-15137 p.
Keyword [en]
Alzheimers disease; fluorescent probes; luminescence; oligothiophenes; microscopy
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-122776DOI: 10.1002/chem.201502999ISI: 000363332200011PubMedID: 26388448OAI: oai:DiVA.org:liu-122776DiVA: diva2:873338
Note

Funding Agencies|Swedish Foundation for Strategic Research; Erling Persson foundation; Alzheimers Disease Research Center (NIH) [AGO 5131]; ERC from the European Research Council; Swedish e-Science Research Center (SeRC); Swedish Research Council [621-2014-4646]

Available from: 2015-11-23 Created: 2015-11-23 Last updated: 2015-11-23

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Shirani, HamidLinares, MathieuLindgren, MikaelNorman, PatrickNilsson, Peter
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