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Within-population Y-linked genetic variation for lifespan in Drosophila melanogaster
Uppsala University, Sweden.
Uppsala University, Sweden; Ecole Normale Super, France.
University of Bielefeld, Germany.
Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Uppsala University, Sweden.ORCID iD: 0000-0001-6112-9586
2015 (English)In: Journal of Evolutionary Biology, ISSN 1010-061X, E-ISSN 1420-9101, Vol. 28, no 11, 1940-1947 p.Article in journal (Refereed) Published
Abstract [en]

The view that the Y chromosome is of little importance for phenotypic evolution stems from early studies of Drosophila melanogaster. This species Y chromosome contains only 13 protein-coding genes, is almost entirely heterochromatic and is not necessary for male viability. Population genetic theory further suggests that non-neutral variation can only be maintained at the Y chromosome under special circumstances. Yet, recent studies suggest that the D.melanogaster Y chromosome trans-regulates hundreds to thousands of X and autosomal genes. This finding suggests that the Y chromosome may play a far more active role in adaptive evolution than has previously been assumed. To evaluate the potential for the Y chromosome to contribute to phenotypic evolution from standing genetic variation, we test for Y-linked variation in lifespan within a population of D.melanogaster. Assessing variation for lifespan provides a powerful test because lifespan (i) shows sexual dimorphism, which the Y is primarily predicted to contribute to, (ii) is influenced by many genes, which provides the Y with many potential regulatory targets and (iii) is sensitive to heterochromatin remodelling, a mechanism through which the Y chromosome is believed to regulate gene expression. Our results show a small but significant effect of the Y chromosome and thus suggest that the Y chromosome has the potential to respond to selection from standing genetic variation. Despite its small effect size, Y-linked variation may still be important, in particular when evolution of sexual dimorphism is genetically constrained elsewhere in the genome.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2015. Vol. 28, no 11, 1940-1947 p.
Keyword [en]
intralocus sexual conflict; longevity; sex chromosomes; sexual dimorphism; Y chromosome
National Category
Biological Sciences
URN: urn:nbn:se:liu:diva-123149DOI: 10.1111/jeb.12708ISI: 000364641900003PubMedID: 26230387OAI: diva2:877626

Funding Agencies|Swedish Foundation for Strategic Research; Carl Tryggers Foundation; Swedish Research Council; German Research Foundation (DFG) [SCHI 1188/1-1]

Available from: 2015-12-07 Created: 2015-12-04 Last updated: 2016-08-31

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