Switchable Bioelectrocatalysis Controlled by Dual Stimuli-Responsive Polymeric Interface
2015 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 7, no 43, 23837-23847 p.Article in journal (Refereed) Published
The engineering of bionanointerfaces using stimuli-responsive polymers offers a new dimension in the design of novel bioelectronic interfaces. The integration of electrode surfaces with stimuli-responsive molecular cues provides a direct control and ability to switch and tune physical and chemical properties of bioelectronic interfaces in various biodevices. Here, we report a dual-responsive biointerface employing a positively responding dual-switchable polymer, poly(NIPAAm-co-DEAEMA)-b-HEAAm, to control and regulate enzyme-based bioelectrocatalysis. The design interface exhibits reversible activation deactivation of bioelectrocatalytic reactions in response to change in temperature and in pH, which allows manipulation of biomolecular interactions to produce on/off switchable conditions. Using electrochemical measurements, we demonstrate that interfacial bioelectrochemical properties can be tuned over a modest range of temperature (i.e., 20-60 degrees C) and pH (i.e., pH 4-8) of the medium. The resulting dual-switchable interface may have important implications not only for the design of responsive biocatalysis and on-demand operation of biosensors, but also as an aid to elucidating electron-transport pathways and mechanisms in living organisms by mimicking the dynamic properties of complex biological environments and processes.
Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2015. Vol. 7, no 43, 23837-23847 p.
stimuli-responsive polymers; tunable biocatalysis; switchable bioelectronics; biointeifaces; triarm polymers; ATRP
Condensed Matter Physics
IdentifiersURN: urn:nbn:se:liu:diva-123136DOI: 10.1021/acsami.5b06048ISI: 000364355500004PubMedID: 26440202OAI: oai:DiVA.org:liu-123136DiVA: diva2:877688
Funding Agencies|Swedish Research Council [VR- 2011-6058357]2015-12-072015-12-042015-12-15