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Switchable Bioelectrocatalysis Controlled by Dual Stimuli-Responsive Polymeric Interface
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. University of Dhaka, Bangladesh.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Faculty of Science & Engineering. Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. UCS, Tekidag AB, SE-58330 Linkoping, Sweden.
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2015 (English)In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 7, no 43, 23837-23847 p.Article in journal (Refereed) Published
Abstract [en]

The engineering of bionanointerfaces using stimuli-responsive polymers offers a new dimension in the design of novel bioelectronic interfaces. The integration of electrode surfaces with stimuli-responsive molecular cues provides a direct control and ability to switch and tune physical and chemical properties of bioelectronic interfaces in various biodevices. Here, we report a dual-responsive biointerface employing a positively responding dual-switchable polymer, poly(NIPAAm-co-DEAEMA)-b-HEAAm, to control and regulate enzyme-based bioelectrocatalysis. The design interface exhibits reversible activation deactivation of bioelectrocatalytic reactions in response to change in temperature and in pH, which allows manipulation of biomolecular interactions to produce on/off switchable conditions. Using electrochemical measurements, we demonstrate that interfacial bioelectrochemical properties can be tuned over a modest range of temperature (i.e., 20-60 degrees C) and pH (i.e., pH 4-8) of the medium. The resulting dual-switchable interface may have important implications not only for the design of responsive biocatalysis and on-demand operation of biosensors, but also as an aid to elucidating electron-transport pathways and mechanisms in living organisms by mimicking the dynamic properties of complex biological environments and processes.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2015. Vol. 7, no 43, 23837-23847 p.
Keyword [en]
stimuli-responsive polymers; tunable biocatalysis; switchable bioelectronics; biointeifaces; triarm polymers; ATRP
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:liu:diva-123136DOI: 10.1021/acsami.5b06048ISI: 000364355500004PubMedID: 26440202OAI: oai:DiVA.org:liu-123136DiVA: diva2:877688
Note

Funding Agencies|Swedish Research Council [VR- 2011-6058357]

Available from: 2015-12-07 Created: 2015-12-04 Last updated: 2015-12-15

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Parlak, OnurTiwari, AshutoshTurner, Anthony
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