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Seasonal variations in vitamin D in relation to growth in short prepubertal children before and during first year growth hormone treatment
University of Gothenburg, Sweden.
University of Gothenburg, Sweden.
Umeå University, Sweden.
University of Gothenburg, Sweden; Angered Hospital, Sweden.
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2015 (English)In: Journal of Endocrinological Investigation, ISSN 0391-4097, E-ISSN 1720-8386, Vol. 38, no 12, 1309-1317 p.Article in journal (Refereed) Published
Abstract [en]

Purpose This study investigated the relationship between seasonal variations in 25-hydroxyvitamin D (25(OH) D) levels and growth in prepubertal children during both the pretreatment year and the first year of GH treatment. Methods The study included 249 short prepubertal children with a broad range of GH secretion, GH(max) during a 24 h profile median 23; range 1-127 mU/L, 191 boys (mean age +/- SD, 8.6 +/- 2.6 years), 58 girls (7.5 +/- 1.9 years) receiving GH treatment (mean 43 mu g/kg/day; range 17-99 mu g/kg/day). Serum 25(OH) D was measured using an automated IDS-iSYS immunoassay. Results 25(OH) D levels showed seasonal variation, and decreased significantly during GH treatment. 25(OH) D levels at start and first year reduction in 25(OH) D, correlated (-) with the first year growth response during treatment. The degree of GH secretion capacity within our study population of mainly non-GH deficient children and 25(OH) D sufficient (67 +/- 29 nmol/L) had no influence on 25(OH) D levels. Growth during GH treatment were independent of seasonal variations in 25(OH) D. Multiple regression analysis showed that 25(OH) D levels at treatment start, together with auxological data and IGF-binding protein-3(SDS), explained 61 % of the variation in first year gain in height(SDS). Conclusion 25(OH) D levels were associated with first year growth response to GH and may be a useful contribution to future growth prediction models.

Place, publisher, year, edition, pages
SPRINGER , 2015. Vol. 38, no 12, 1309-1317 p.
Keyword [en]
25-Hydroxyvitamin D; Growth hormone; Growth response
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-123131DOI: 10.1007/s40618-015-0360-1ISI: 000364394400007PubMedID: 26253710OAI: oai:DiVA.org:liu-123131DiVA: diva2:877721
Note

Funding Agencies|Pharmacia/Pfizer; Swedish Research Council [7509]; Wilhelm and Martina Lundgrens Foundation; Wera Ekstroms Foundation for Pediatric Research; Foundation Vaxthuset for Children; Sahlgrenska University Hospital (ALF); West Sweden Region (VGR) grants; County Council of Ostergotland; Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences; Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden

Available from: 2015-12-07 Created: 2015-12-04 Last updated: 2015-12-07

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Magnusson, Per
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Division of Microbiology and Molecular MedicineDepartment of Clinical ChemistryFaculty of Medicine and Health Sciences
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