liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Seasonal variations in vitamin D in relation to growth in short prepubertal children before and during first year growth hormone treatment
University of Gothenburg, Sweden.
University of Gothenburg, Sweden.
Umeå University, Sweden.
University of Gothenburg, Sweden; Angered Hospital, Sweden.
Show others and affiliations
2015 (English)In: Journal of Endocrinological Investigation, ISSN 0391-4097, E-ISSN 1720-8386, Vol. 38, no 12, 1309-1317 p.Article in journal (Refereed) Published
Abstract [en]

Purpose This study investigated the relationship between seasonal variations in 25-hydroxyvitamin D (25(OH) D) levels and growth in prepubertal children during both the pretreatment year and the first year of GH treatment. Methods The study included 249 short prepubertal children with a broad range of GH secretion, GH(max) during a 24 h profile median 23; range 1-127 mU/L, 191 boys (mean age +/- SD, 8.6 +/- 2.6 years), 58 girls (7.5 +/- 1.9 years) receiving GH treatment (mean 43 mu g/kg/day; range 17-99 mu g/kg/day). Serum 25(OH) D was measured using an automated IDS-iSYS immunoassay. Results 25(OH) D levels showed seasonal variation, and decreased significantly during GH treatment. 25(OH) D levels at start and first year reduction in 25(OH) D, correlated (-) with the first year growth response during treatment. The degree of GH secretion capacity within our study population of mainly non-GH deficient children and 25(OH) D sufficient (67 +/- 29 nmol/L) had no influence on 25(OH) D levels. Growth during GH treatment were independent of seasonal variations in 25(OH) D. Multiple regression analysis showed that 25(OH) D levels at treatment start, together with auxological data and IGF-binding protein-3(SDS), explained 61 % of the variation in first year gain in height(SDS). Conclusion 25(OH) D levels were associated with first year growth response to GH and may be a useful contribution to future growth prediction models.

Place, publisher, year, edition, pages
SPRINGER , 2015. Vol. 38, no 12, 1309-1317 p.
Keyword [en]
25-Hydroxyvitamin D; Growth hormone; Growth response
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-123131DOI: 10.1007/s40618-015-0360-1ISI: 000364394400007PubMedID: 26253710OAI: diva2:877721

Funding Agencies|Pharmacia/Pfizer; Swedish Research Council [7509]; Wilhelm and Martina Lundgrens Foundation; Wera Ekstroms Foundation for Pediatric Research; Foundation Vaxthuset for Children; Sahlgrenska University Hospital (ALF); West Sweden Region (VGR) grants; County Council of Ostergotland; Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences; Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden

Available from: 2015-12-07 Created: 2015-12-04 Last updated: 2015-12-07

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Magnusson, Per
By organisation
Division of Microbiology and Molecular MedicineDepartment of Clinical ChemistryFaculty of Medicine and Health Sciences
In the same journal
Journal of Endocrinological Investigation
Clinical Medicine

Search outside of DiVA

GoogleGoogle ScholarTotal: 1 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 141 hits
ReferencesLink to record
Permanent link

Direct link