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Safety and efficacy of composite collagen-silver nanoparticle hydrogels as tissue engineering scaffolds
University of Ottawa, Canada; University of Ottawa, Canada; University of Ottawa, Canada.
Karolinska Institute, Sweden.
University of Ottawa, Canada; .
University of Ottawa, Canada.
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2015 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 7, no 44, 18789-18798 p.Article in journal (Refereed) PublishedText
Abstract [en]

The increasing number of multidrug resistant bacteria has revitalized interest in seeking alternative sources for controlling bacterial infection. Silver nanoparticles (AgNPs), are amongst the most promising candidates due to their wide microbial spectrum of action. In this work, we report on the safety and efficacy of the incorporation of collagen coated AgNPs into collagen hydrogels for tissue engineering. The resulting hybrid materials at [AgNPs] less than0.4 mu M retained the mechanical properties and biocompatibility for primary human skin fibroblasts and keratinocytes of collagen hydrogels; they also displayed remarkable anti-infective properties against S. aureus, S. epidermidis, E. coli and P. aeruginosa at considerably lower concentrations than silver nitrate. Further, subcutaneous implants of materials containing 0.2 mu M AgNPs in mice showed a reduction in the levels of IL-6 and other inflammation markers (CCL24, sTNFR-2, and TIMP1). Finally, an analysis of silver contents in implanted mice showed that silver accumulation primarily occurred within the tissue surrounding the implant.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015. Vol. 7, no 44, 18789-18798 p.
National Category
Physical Sciences Clinical Medicine
URN: urn:nbn:se:liu:diva-123536DOI: 10.1039/c5nr03826jISI: 000364824000048PubMedID: 26507748OAI: diva2:886136

Funding Agencies|Natural Sciences and Engineering Research Council of Canada; NSERC/CIHR Canada; Swedish Research Council [621-2010-5189]; AFA Forsakring; University of Ottawa Heart Institute Startup grant

Available from: 2015-12-21 Created: 2015-12-21 Last updated: 2016-01-12Bibliographically approved

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Available from 2016-09-29 00:00

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Islam, Mohammed MirazulLee, Chyan-JangScaiano, JuanGriffith, May
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