liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Psychiatric symptoms in adolescents: FKBP5 genotype-early life adversity interaction effects
Uppsala University, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Child and Adolescent Psychiatry in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
Show others and affiliations
2015 (English)In: European Child and Adolescent Psychiatry, ISSN 1018-8827, E-ISSN 1435-165X, Vol. 24, no 12, 1473-1483 p.Article in journal (Refereed) PublishedText
Abstract [en]

Psychiatric disorders are multi-factorial and their symptoms overlap. Constitutional and environmental factors influence each other, and this contributes to risk and resilience in mental ill-health. We investigated functional genetic variation of stress responsiveness, assessed as FKBP5 genotype, in relation to early life adversity and mental health in two samples of adolescents. One population-based sample of 909 12-year-old adolescents was assessed using the Life Incidence of Traumatic Events scale and the Strengths and Difficulties Questionnaire. One sample of 398 17-year-old adolescents, enriched for poly-victimized individuals (USSS), was assessed using the Juvenile Victimization Questionnaire and the Trauma Symptom Checklist for Children (TSCC). The FKBP5 rs1360780 and rs3800373 polymorphisms were genotyped using a fluorescence-based competitive allele-specific PCR. Most prominently among poly-victimized older male adolescents, the least common alleles of the polymorphisms, in interaction with adverse life events, were associated with psychiatric symptoms, after controlling for ethno-socio-economic factors. The interaction effect between rs3800373 and adverse life events on the TSCC sub-scales-anxiety, depression, anger, and dissociation-and with the rs1360780 on dissociation in the USSS cohort remained significant after Bonferroni correction. This pattern of association is in line with the findings of clinical and neuroimaging studies, and implies interactive effects of FKBP5 polymorphisms and early life environment on several psychiatric symptoms. These correlates add up to provide constructs that are relevant to several psychiatric symptoms, and to identify early predictors of mental ill-health.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 24, no 12, 1473-1483 p.
Keyword [en]
Adolescents; FKBP5; Gene; Mental health; Stress
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-123510DOI: 10.1007/s00787-015-0768-3ISI: 000365191700005PubMedID: 26424511OAI: oai:DiVA.org:liu-123510DiVA: diva2:886294
Note

Funding Agencies|Swedish Crime Victim Compensation and Support Authority [09042/2008]; Swedish Council for Working Life and Social Research; Swedish Council for Working Life and Social Research [2011-0627]; Uppsala University

Available from: 2015-12-22 Created: 2015-12-21 Last updated: 2016-03-11Bibliographically approved

Open Access in DiVA

The full text will be freely available from 2016-09-30 08:15
Available from 2016-09-30 08:15

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gustafsson, PerSydsjö, GunillaAgnafors, SaraAho, NikolasSvedin, Carl Göran
By organisation
Division of Clinical SciencesFaculty of Medicine and Health SciencesDepartment of Child and Adolescent Psychiatry in LinköpingDepartment of Gynaecology and Obstetrics in LinköpingDivision of Neuro and Inflammation Science
In the same journal
European Child and Adolescent Psychiatry
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 198 hits
ReferencesLink to record
Permanent link

Direct link