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Lateral-flow technology: from visual to instrumental.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0003-3274-6029
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering.
Linköping University, Department of Physics, Chemistry and Biology, Biosensors and Bioelectronics. Linköping University, Faculty of Science & Engineering. (Biosensors & Bioelectronics)ORCID iD: 0000-0002-1815-9699
2016 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 79, no SI, 297-305 p.Article in journal (Refereed) Published
Abstract [en]

Lateral-flow tests were first launched commercially in 1984, as a simple urine-based pregnancy test for home use. The simplicity of the visual readout delivered by the basic lateral-flow format proved to be a very popular. However, the recent apparently unstoppable trend towards portable and wearable technology is driving the lateral-flow strip towards an industrial interface that will enable it to interface with big data and expert systems, and where ready transmission of data is essential. In this review, we chart the inevitable evolution of the visually-read lateral-flow strip to more advanced instrumented versions and consider the future of this very flexible approach to delivering simple affinity assays. We examine recent labelling strategies, the relative merits of optical and electrochemical transducers and explore the evolution of recognition elements that are now being incorporated into these systems.

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 79, no SI, 297-305 p.
Keyword [en]
Lateral-flow immunoassay; immunochromatography; paper-based diagnostics; visually-read assays; mobile phone diagnostics; cell phone assays; electrochemical immunoassay; gold nanoparticles; printed electronics; nucleic acid tests
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-123687DOI: 10.1016/j.trac.2015.10.017ISI: 000376703900030OAI: oai:DiVA.org:liu-123687DiVA: diva2:891955
Available from: 2016-01-08 Created: 2016-01-08 Last updated: 2016-06-27

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Mak, Wing CheungBeni, ValerioTurner, Anthony
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