Matrix Addressing of an Electronic Surface Switch Based on a Conjugated Polyelectrolyte for Cell Sorting
2015 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 25, no 45, 7056-7063 p.Article in journal (Refereed) PublishedText
Spatial control of cell detachment is potentially of great interest when selecting cells for clonal expansion and in order to obtain a homogeneous starting population of cells aimed for tissue engineering purposes. Here, selective detachment and cell sorting of human primary keratinocytes and fibroblasts is achieved using thin films of a conjugated polymer. Upon electrochemical oxidation, the polymer film swells, cracks, and finally detaches taking cells cultured on top along with it. The polymer can be patterned using standard photolithography to fabricate a cross-point matrix with polymer pixels that can be individually addressed and thus detached. Detachment occurs above a well-defined threshold of +0.7 V versus Ag/AgCl, allowing the use of a relatively simple and easily manufactured passive matrix-addressing configuration, based on a resistor network, to control the cell-sorting device.
Place, publisher, year, edition, pages
WILEY-V C H VERLAG GMBH , 2015. Vol. 25, no 45, 7056-7063 p.
Clinical Medicine Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:liu:diva-123754DOI: 10.1002/adfm.201503542ISI: 000366502900010OAI: oai:DiVA.org:liu-123754DiVA: diva2:892977
Funding Agencies|Swedish Foundation for Strategic Research; VINNOVA (the OBOE center) [2010-00507]; Onnesjo foundation (Holmen); Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]2016-01-112016-01-112016-01-11