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Vasoactive Peptide Levels after Change of Dialysis Mode.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Nephrology.
Karolinska University Hospital, Huddinge, Stockholm .
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Region Östergötland, Heart and Medicine Center, Department of Nephrology. Linköping University, Faculty of Medicine and Health Sciences.
2015 (English)In: Nephron Extra, ISSN 1664-5529, Vol. 5, no 3, 68-78 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/AIMS: Plasma concentrations of the N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) are increased in end-stage renal disease. Improvement in hemodynamic stability has been reported when switching from hemodialysis (HD) to on-line hemodiafiltration (ol-HDF). The aim of this study was to investigate plasma concentrations of NT-proBNP, BNP and neuropeptide Y (NPY) during a 1-year follow-up, after a change from high-flux HD to postdilution ol-HDF. Additional variables were also studied, e.g. pulse wave velocity and ordinary clinical parameters.

METHOD: We conducted a prospective, single-center study including 35 patients who were switched from HD to HDF. Plasma concentrations of NT-proBNP, BNP and NPY before and after dialysis were measured at baseline (i.e. HD) and at 1, 2, 4, 6 and 12 months on HDF.

RESULTS: All three peptide levels decreased significantly during HD and HDF when comparing concentrations before and after dialysis. Mean absolute value (before/after) and relative decrease (%) before versus after dialysis was 13.697/9.497 ng/l (31%) for NT-proBNP, 62/40 ng/ml (35%) for BNP and 664/364 pg/l (45%) for NPY. No significant differences were observed when comparing predialysis values over time. However, postdialysis NT-proBNP concentration showed a significant decrease of 48% over time after the switch to HDF.

CONCLUSION: The postdialysis plasma levels of NT-proBNP, BNP and NPY decreased significantly during both dialysis modes when compared to before dialysis. The postdialysis lowering of NT-proBNP increased further over time after the switch to ol-HDF; the predialysis levels were unchanged, suggesting no effect on its production in the ventricles of the heart.

Place, publisher, year, edition, pages
2015. Vol. 5, no 3, 68-78 p.
Keyword [en]
Convective therapies; Hemodiafiltration; N-terminal fragment of pro-brain natriuretic peptide; Neuropeptide Y; Vasoactive peptides
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:liu:diva-124043DOI: 10.1159/000440816PubMedID: 26648973OAI: oai:DiVA.org:liu-124043DiVA: diva2:895266
Available from: 2016-01-18 Created: 2016-01-18 Last updated: 2016-04-30

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Uhlin, FredrikTheodorsson, ElvarFernström, Anders
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Department of Medical and Health SciencesFaculty of Medicine and Health SciencesDepartment of NephrologyDivision of Microbiology and Molecular MedicineDepartment of Clinical ChemistryDivision of Drug Research
Pharmaceutical Sciences

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