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After 6years of intraperitoneal insulin administration IGF-I concentrations in T1DM patients are at low-normal level.
Isala, Diabetes Centre, Zwolle, The Netherlands.
University Medical Center Groningen, The Netherlands.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Endocrinology.
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2015 (English)In: Growth Hormone & IGF Research, ISSN 1096-6374, E-ISSN 1532-2238, Vol. 25, no 6, 316-319 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Low concentrations of insulin-like growth factor-I (IGFI) have been reported in type 1 diabetes mellitus (T1DM), suggested to be due to low insulin concentrations in the portal vein. The aim was to describe the long-term course of IGFI concentrations among T1DM subjects treated with continuous intraperitoneal (IP) insulin infusion (CIPII).

DESIGN: Nineteen patients that participated in a randomized cross-over trial comparing CIPII and subcutaneous (SC) insulin therapy in 2006 were followed until 2012. IGF-I measurements were performed at the start of the 2006 study, after the 6month SC- and CIPII treatment phase in 2006 and during CIPII therapy in 2012. Z-scores were calculated to compare the IGF-I concentrations with age-specific normative range values of a non-DM reference population.

RESULTS: In 2012, IGF-I Z-scores (-0.7; 95% confidence interval -1.3, -0.2) were significantly higher than at the start of the 2006 study (-2.5; -3.3, -1.8), the end of the SC (-2.0; -2.6, -1.5) and CIPII (-1.6; -2.1, -1.0) treatment phase with a mean difference of: 1.8 (0.9, 2.7), 1.3 (0.5, 2.1) and 0.8 (0.1, 1.6), respectively.

CONCLUSION: After 6years of treatment with CIPII, IGF-I concentrations among T1DM patients increased to a level that is higher than during prior SC insulin treatment and is in the lower normal range compared to a non-DM reference population. The results of this study suggest that long-term IP insulin administration influences the IGF system in T1DM.

Place, publisher, year, edition, pages
2015. Vol. 25, no 6, 316-319 p.
Keyword [en]
IGF-I; Intraperitoneal insulin; Type 1 diabetes mellitus
National Category
Endocrinology and Diabetes Physiology
Identifiers
URN: urn:nbn:se:liu:diva-124061DOI: 10.1016/j.ghir.2015.08.007ISI: 000366962800009PubMedID: 26336814OAI: oai:DiVA.org:liu-124061DiVA: diva2:895648
Note

Funding agencies: Medical Research Council of Southeast Sweden (FORSS); Stichting Zwols Wetenschapsfonds Isala Klinieken (ZWIK)

Available from: 2016-01-19 Created: 2016-01-19 Last updated: 2016-04-12

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Chisalita, Ioana SimonaHedman, Christina A.Arnqvist, Hans J.
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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Emergency MedicineDivision of Cardiovascular MedicineDepartment of EndocrinologyDivision of Cell Biology
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Growth Hormone & IGF Research
Endocrinology and DiabetesPhysiology

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