Apoptosis, autophagy and unfolded proteinresponse pathways in Arbovirus replicationand pathogenesis
2016 (English)In: Expert Reviews in Molecular Medicine, ISSN 1462-3994, E-ISSN 1462-3994, Vol. 18, no e1, 21- p.Article, review/survey (Refereed) Published
Arboviruses are pathogens that widely affect the health of people in different communities around the world. Recently, a few successful approaches toward production of effective vaccines against some of these pathogens have been developed, but treatment and prevention of the resulting diseases remain a major health and research concern. The arbovirus infection and replication processes are complex, and many factors are involved in their regulation. Apoptosis, autophagy and the unfolded protein response (UPR) are three mechanisms that are involved in pathogenesis of many viruses. In this review, we focus on the importance of these pathways in the arbovirus replication and infection processes. We provide a brief introduction on how apoptosis, autophagy and the UPR are initiated and regulated, and then discuss the involvement of these pathways in regulation of arbovirus pathogenesis.
Place, publisher, year, edition, pages
Cambridge University Press, 2016. Vol. 18, no e1, 21- p.
apoptosis; cell death, viral infection;
Microbiology in the medical area
IdentifiersURN: urn:nbn:se:liu:diva-124168DOI: 10.1017/erm.2015.19ISI: 000368708700001PubMedID: 26781343OAI: oai:DiVA.org:liu-124168DiVA: diva2:896082
Funding agencies: University of Manitoba; Manitoba Medical Service Foundation; Canadian Institutes of Health Research [MT-11630]2016-01-202016-01-202016-03-10