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Chapter 31  Valvular Interstitial Cells
Department of Cardiothoracic Surgery, Stanford University School of Medicine; Research Institute of the Palo Alto Medical Foundation, Palo Alto, USA.
Linköping University, Department of Management and Engineering, Applied Thermodynamics and Fluid Mechanics. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0001-5526-2399
2016 (English)In: Mitral Valve Mechanics / [ed] Neil B Ingels, Jr and Matts Karlsson, Linköping University Electronic Press, 2016, 31.1-31.1 p.Chapter in book (Other academic)
Abstract [en]

The stiffening "twitch" of the annular half of the anterior mitral leaflet at the beginning of each beat likely arises from P-wave-stimulated, β-dependent, neurally-insensitive myocytes located in this region. The source of the ubiquitous, β-independent, neurally-sensitive, steady-state stiffness "tone" of the entire anterior leaflet is less clear, but may involve contractile Valvular Interstitial Cells (VICs) bound to leaflet collagen by α2β1 integrins, as discussed by Stephens et al.

Place, publisher, year, edition, pages
Linköping University Electronic Press, 2016. 31.1-31.1 p.
National Category
Fluid Mechanics and Acoustics
URN: urn:nbn:se:liu:diva-124248ISBN: 978-91-7685-952-0OAI: diva2:897141
Available from: 2016-01-25 Created: 2016-01-25 Last updated: 2016-03-14

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