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Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease
Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
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2016 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 279, no 1, 63-77 p.Article in journal (Refereed) Published
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Abstract [en]

ObjectiveRegulatory T cells (Tregs) are considered atheroprotective, and low levels have been associated with the acute coronary syndrome (ACS), particularly non-ST elevation (NSTE)-ACS. However, the functional properties as well as homeostasis of Tregs are mainly unknown in coronary artery disease (CAD). Here, we investigated the composition and functional properties of naive (n) and memory (m)Tregs in patients with NSTE-ACS and in patients 6-12months post-ACS. MethodsBased on the expression of CD25, FOXP3, CD127, CD45RA, CD39 and CTLA-4, Tregsubsets were defined by flow cytometry in whole blood or isolated CD4(+) T cells. The functional properties of nTregs and mTregs were examined in terms of proliferative capacity and modulation of cytokine secretion. To understand the potential consequences of Treg defects, we also investigated correlations with lipopolysaccharide (LPS)-induced cytokine secretion and ultrasound-defined carotid atherosclerosis. ResultsBoth NSTE-ACS and post-ACS patients exhibited reduced levels of nTregs (P<0.001) compared with healthy control subjects, but without compensatory increases in mTregs. Both nTregs and mTregs from patients showed significantly lower replicative rates and impaired capacity to modulate T-cell proliferation and secretion of interferon-gamma and IL-10. The Treg defect was also associated with LPS-induced cytokine secretion and increased burden of carotid atherosclerosis. ConclusionOur results demonstrate a functional and homeostatic Treg defect in patients with NSTE-ACS and also in stabilized patients 6-12months after ACS. Moreover, this defect was associated with a subclinical proinflammatory and atherogenic state. We believe that the failure to preserve Treg function and homeostasis reflects a need for immune-restoring strategies in CAD.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2016. Vol. 279, no 1, 63-77 p.
Keyword [en]
acute coronary syndrome; coronary artery disease; immune homeostasis; inflammation; regulatory T cell
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-124108DOI: 10.1111/joim.12398ISI: 000366606200006PubMedID: 26260103OAI: oai:DiVA.org:liu-124108DiVA: diva2:897169
Note

Funding Agencies|Swedish Medical Research Council; Swedish Heart-Lung Foundation

Available from: 2016-01-25 Created: 2016-01-19 Last updated: 2017-04-25

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Hasib, LekbiraLundberg, AnnaZachrisson, HeleneErnerudh, JanJonasson, Lena

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Faculty of Medicine and Health SciencesDivision of Cardiovascular MedicineDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)Division of Neuro and Inflammation ScienceDepartment of Clinical Immunology and Transfusion MedicineDepartment of Cardiology in Linköping
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