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Association of elevated rotavirus-specific antibody titers with HBGA secretor status in Swedish individuals: The FUT2 gene as a putative susceptibility determinant for infection
Karolinska Institute, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Karolinska Institute, Sweden.
2016 (English)In: Virus Research, ISSN 0168-1702, E-ISSN 1872-7492, Vol. 211, 64-68 p.Article in journal (Refereed) PublishedText
Abstract [en]

The histo-blood group antigens (HBGAs) have recently been suggested to serve as attachment factors for rotavirus VP8* (P-genotype) in vitro and associated with susceptibility in vivo. We thus investigated whether rotavirus antibody titers and genotype specific neutralization titers correlate with HBGA status in Swedish individuals. We investigated the effect of inactivating mutations in the secretor FUT2 (rs601338) and Lewis FUT3 genes (rs28362459, rs3894326, rs812936 and rs778986) on serum IgG antibody titers and neutralizing antibody titers to rotavirus strains of the P[8] and P[6] genotypes in Swedish healthy blood donors and patients with IgA deficiency using genotyping, enzyme linked immunosorbent assay and a neutralization assay. Rotavirus-specific serum IgG and neutralizing antibody titers to the Wa strain (G1P[8]), but not to the ST3 (G4P[6]) strain, were significantly higher in secretors (with at least one functional FUT2 gene) than in non-secretors (P<0.001) (with homozygous nonsense mutation in the FUT2 gene). Thus, our results represent that secretors show elevated rotavirus specific serum antibodies, suggesting a higher susceptibility to rotavirus infections, as compared to non-secretors in Sweden. (C) 2015 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2016. Vol. 211, 64-68 p.
Keyword [en]
Rotavirus; Histo-blood group antigen (HBGA); FUT2; Lewis; Secretor; Antibody response
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-124088DOI: 10.1016/j.virusres.2015.10.005ISI: 000366443500009PubMedID: 26454189OAI: oai:DiVA.org:liu-124088DiVA: diva2:897223
Note

Funding Agencies|Swedish Research Council [K2012-56X-05975-32-3]

Available from: 2016-01-25 Created: 2016-01-19 Last updated: 2016-01-25

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Nordgren, JohanSharma, Sumit
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