liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Use of tramadol in early pregnancy and congenital malformation risk
Lund University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Skåne University Hospital, Sweden.ORCID iD: 0000-0002-6041-0744
2015 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 58, 246-251 p.Article in journal (Refereed) PublishedText
Abstract [en]

Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1,682,846 women (1,797,678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. (C) 2015 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2015. Vol. 58, 246-251 p.
Keyword [en]
Congenital malformations; Opioids; Pes equinovarus; Cardiovascular defects; Tramadol
National Category
Clinical Medicine
URN: urn:nbn:se:liu:diva-124508DOI: 10.1016/j.reprotox.2015.10.007ISI: 000367559600030PubMedID: 26482725OAI: diva2:899580
Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2016-02-23

Open Access in DiVA

The full text will be freely available from 2016-10-23 00:00
Available from 2016-10-23 00:00

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Reis, Margareta
By organisation
Division of Drug ResearchFaculty of Medicine and Health Sciences
In the same journal
Reproductive Toxicology
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 117 hits
ReferencesLink to record
Permanent link

Direct link