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Use of tramadol in early pregnancy and congenital malformation risk
Lund University, Sweden.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Skåne University Hospital, Sweden.ORCID iD: 0000-0002-6041-0744
2015 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 58, 246-251 p.Article in journal (Refereed) PublishedText
Abstract [en]

Only few studies exist regarding the risk of a teratogenic effect of tramadol when used in early pregnancy. Using the Swedish Medical Birth Register, women (deliveries in 1997-2013) who had reported the use of tramadol in early pregnancy were identified. Maternal characteristics and concomitant drug use were analyzed. Among 1,682,846 women (1,797,678 infants), 1751 (1776 infants) had used tramadol, 96 of the infants had a congenital malformation and 70 of them were relatively severe. The adjusted odds ratio for a relatively severe malformation was 1.33 (95% CI 1.05-1.70). The odds ratios for cardiovascular defects (1.56, 95% CI 1.04-2.29) and for pes equinovarus (3.63, 95% CI 1.61-6.89) were significantly increased. The study suggests a teratogenic effect of tramadol but the risk increase is moderate. (C) 2015 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2015. Vol. 58, 246-251 p.
Keyword [en]
Congenital malformations; Opioids; Pes equinovarus; Cardiovascular defects; Tramadol
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-124508DOI: 10.1016/j.reprotox.2015.10.007ISI: 000367559600030PubMedID: 26482725OAI: oai:DiVA.org:liu-124508DiVA: diva2:899580
Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2016-02-23

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Available from 2016-10-23 00:00

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Reis, Margareta
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